Research Studies that Have Used RTube™

2024

Exhaled breath condensate contains extracellular vesicles (EVs) that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed

MI Mitchell, IZ Ben‐Dov, K Ye, C Liu… – Journal of …, 2024 – Wiley Online Library

… We first sought to determine whether EBC collected with the RTube™ device allowed for
the condensation of exhaled EVs (exh-EVs). For this, we evaluated the purification of exh-EVs …

Biomimetic, Phase-Change Microsystems for Breath Condensate Based Point-of-Care Diagnostics

P Morales-Cruz, M Tregansin, J Fnu… – 2024 IEEE 37th …, 2024 – ieeexplore.ieee.org

… The lack of cohesion in the field has also led to a stagnation in progress and this is further
exacerbated by the lack of options on the market for breath condensate collection [11]. RTube […

Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields

YJ Choi, MJ Lee, MK Byun, S Park, J Park… – Tuberculosis and …, 2024 – ncbi.nlm.nih.gov

… The subjects immediately begin breathing in and out through the RTube mouthpiece. The
one… end of the RTube. We used the plunger to collect EBC into the cap at the top of the RTube. …

The role of volatile organic compounds for assessing characteristics and severity of non-cystic fibrosis bronchiectasis: an observational study

SY Gu, HW Lu, JW Bai, JW Yang, B Mao, L Yu… – Frontiers in …, 2024 – frontiersin.org

… All the Rtube exhaled breath condensate collector were disposable design ensures a
clean device ready for use at any time with no risk of infectious disease transmission between …

Effect of elexacaftor/tezacaftor/ivacaftor on mucus and mucociliary clearance in cystic fibrosis

SH Donaldson, TE Corcoran, JM Pilewski… – Journal of Cystic …, 2024 – Elsevier

… into this prospective, observational trial prior to initiation of E/T/I and had baseline measurement
of MCC and characterization of induced sputum and exhaled breath condensate (EBC) …

A Clinical Breathomics Dataset

PH Kuo, YC Jhong, TC Kuo, YT Hsu, CH Kuo… – Scientific Data, 2024 – nature.com

… Samples of exhaled breath condensate (EBC) were collected from healthy individuals
using the commercial device RTube ® (Respiratory Research, Charlottesville, VA, USA). The …

Exhaled breath analysis of non-volatile drugs: Towards clinical applications

H Huang, J Yang, C Tao, L Hu, T Huan… – TrAC Trends in …, 2024 – Elsevier

… (b) RTube™ is a commercially available portable and disposable collection system that …
Exhaled breath condensate (EBC) is the liquid that results from the condensation of human …

A concise review of exhaled breath testing for respiratory clinicians and researchers

R Wang, MD Davis – Respiratory Care, 2024 – rc.rcjournal.com

… Clinical metabolomics of exhaled breath condensate in chronic respiratory diseases. Adv …
Point-of-care exhaled breath condensate collection and analysis devices for SARS-CoV2 virus …

Ανάπτυξη υπολογιστικών βιοδεικτών της δύσπνοιας ασθενών με χρόνια αποφρακτική πνευμονοπάθεια (ΧΑΠ)

Σ Πατσίρης – 2024 – didaktorika.gr

… Η συλλογή και η ανάλυση του συμπυκνώματος του εκπνεόμενου αέρα πραγματοποιήθηκαν
με το RTube και την συσκευή Accusizer μοντέλο 780SIS και FxNano, αντίστοιχα. Ενώ για την …

2023

Advances in proteomics methods for the analysis of exhaled breath condensate

EJ Yoo, JS Kim, S Stransky, S Spivack… – Mass Spectrometry …, 2023 – Wiley Online Library

… Limitations of this study included the max sample volume collected by the RTube®. Gade
et al. did a study investigating pulmonary embolism (PE) in pigs (Gade et al., 2021); the follow-…

A clinical proteomics study of exhaled breath condensate and biomarkers for pulmonary embolism

IL Gade, SJ Riddersholm… – Journal of Breath …, 2023 – iopscience.iop.org

… We pre-cooled the RTube aluminium cooling sleeve to −80 C and kept it at dry ice during
the transport to the patient. An insulating cover was placed over the aluminium cooling sleeves …

MEASURE: Multiplex Exhaled Breath Condensate–Scanning Using Rapid Electro-Analytics

A Bhide, MA Eldeeb, M Pali, S Muthukumar… – ACS …, 2023 – ACS Publications

… with a breath condensate collection device, RTube registered with the FDA that was procured
from Respiratory Research, Inc. (Austin, TX, USA). The disposable RTube collector tubes …

microRNAs in exhaled breath condensate for diagnosis of lung cancer in a resource-limited setting: a concise review

D Rai, B Pattnaik, S Bangaru, J Tak, J Kumari… – Breathe, 2023 – Eur Respiratory Soc

… Of these, the RTube system is associated with a greater … Furthermore, the RTube system
has added advantages of … The RTube consists of a T-shaped polypropylene condensation …

Stable COPD Picture through Exhaled Breath Condensate, Questionnaires and Tests. A Proof of Concept Study

S Patsiris, A Afthinos, L Augouste, K Valsami… – Age (yrs …, 2023 – pulmonolrespirjournal.com

… picture via the relationship between exhaled breath condensate (EBC) particle concentration
and … The EBC was collected with Rtube and analyzed using the Accusizer FxNano. Particle …

Metabolomic Analysis Identifies Differences in Energy Metabolism in Exhaled Breath Condensate From Patients With Radiation-induced Lung Fibrosis

J Pierre-Louis, MAT Freeberg, SV Camus… – A68 …, 2023 – atsjournals.org

… We analyzed exhaled breath condensate (EBC), a natural matrix of the respiratory tract
that represents the composition of the lung lining fluid. EBC was collected using the Rtube …

Initial development and testing of an exhaled microRNA detection strategy for lung cancer case–control discrimination

M Shi, W Han, O Loudig, CD Shah, JB Dobkin… – Scientific reports, 2023 – nature.com

… the simple handheld RTube device are: (i… condensate from the RTube after collection. Briefly,
before any clinically-indicated lung procedure, seated subjects were equipped with RTube /…

Presence of fetal DNA in maternal exhaled breath condensate

S Tıplamaz, İP Eyüboğlu, C Ünal, Ö Soyer… – Prenatal …, 2023 – Wiley Online Library

… Exhaled breath condensate is a non-invasive method for sampling exhaled air. It has been
… The Rtube TM is the second method frequently used. Both systems have pros and cons, but …

Oxylipin concentration shift in exhaled breath condensate (EBC) of SARS-CoV-2 infected patients

E Borras, MM McCartney, DE Rojas… – Journal of Breath …, 2023 – iopscience.iop.org

… EBC samples were collected using condensate collection devices previously reported [11,
31]; and the EBC samples were lyophilized, reconstituted, and then analyzed using LC-MS. …

Exhaled breath condensate specimens for testing airway health during exercise

M Peng, X Yang, L Xing, G Li – Chinese Journal of Tissue Engineering …, 2023 – cjter.com

… by exhaled breath condensate detection during intense … biomarkers in exhaled breath
condensate for detecting the airway … ,美国的 RTube,德国的 EcoScreen,其中 RTube 和 Turbodecss …

Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women

JRJR STENCZER, G LOSONCZY, I HORVÁTH… – academia.edu

… Condensate samples were collected for 10 min using a handheld device (RTube, … The
chiller tube was held at À80C before condensate collection. Samples were stored at À80C in …

Rolosense: Mechanical detection of SARS-CoV-2 using a DNA-based motor

S Piranej, L Zhang, A Bazrafshan, M Marin… – bioRxiv, 2023 – ncbi.nlm.nih.gov

… Our results indicate that breath condensate did not affect the robustness of our assay as …
RTube ™ breath condensate collection device was purchased from Respiratory Research (…

Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia

CW Course, PA Lewis, SJ Kotecha, M Cousins… – Scientific Reports, 2023 – nature.com

… We characterised the exhaled breath condensate (EBC) proteome in preterm-born children,
… respiratory testing including collection of EBC (RTube®, Respiratory Research Inc. Texas, …

The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and …

N Drabińska, J Romaszko, P White – Plos one, 2023 – journals.plos.org

… Exhaled breath condensate samples will be collected using commercial sampling tubes (RTubes),
which allow for the collection of approx. 3 mL condensate within 10 minutes. All the …

Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score

K Rubio, JM Müller, A Mehta, I Watermann, T Olchers… – Discover Oncology, 2023 – Springer

… loci, which are detected in exhaled breath condensates (EBCs). Levels of these …
RTube (Respiratory Research) as described online (http://www.res piratoryresearch.com/products-rtube

Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia

CW Course, PA Lewis, SJ Kotecha, M Cousins… – Scientific Reports, 2023 – nature.com

… We characterised the exhaled breath condensate (EBC) metabolome from preterm-born …
EBC was collected in a standardised manner using a cooling tube (RTube®, Respiratory …

Hands-on: Hands-on: Annotating a protein list identified by LC-MS/MS experiments

V Loux, F Combes, D Christiany, Y Vandenbrouck – 2023 – usegalaxy.fr

… Samples were obtained non-invasively by condensation of exhaled air that contains … As
EBC samples are obtained from air exhaled through the oral cavity, and even though the RTube …

Biopsia dychu: potenciálny zdroj DNA pre biomedicínske aplikácie

O Pös, M Kubáňová, J Styk, S Bokorová, W Krampl… – časopis laboratórnej … – newslab.sk

… exhaled breath condensate; EBC). V štúdiách boli na zber tohto typu vzorky opísané
rôzne customizované aj komerčne dostupné systémy, ako sú RTube, EcoScreen, TURBO-DECCS …

Odrębności bakteryjnej mikrobioty dróg oddechowych dzieci chorujących na astmę oskrzelową

K Bar – 2023 – ppm.umw.edu.pl

… and exhaled breath condensate, with use of RTube kit, were … alpha-diversity than exhaled
breath condensates. The bacterial … correlated in exhaled breath condensates samples. Factors …

2022

A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection

Sergio Fabián Mosquera-Restrepo, Sophie Zuberogoïtia, … Jérôme Nigou  2022 – Nature Communications volume 13,\

…The EBCs were collected using R-tubes (Respiratory Research, Inc). The R-tube is a non-invasive device that allows the collection and condensation of components of the expiration.

Characterization of the elemental and particle load of patient exhaled breath condensate and comparison with pulmonary lavages

C Marie-Desvergne, M Dubosson… – Journal of Breath …, 2022 – iopscience.iop.org

… In order to validate the efficiency of the washing procedure of the RTubes, eight blank
RTubes filled with 1.5 ml of ultrapure water after the seven washings with ultrapure water were …

Detection of respiratory inflammation biomarkers in non-processed exhaled breath condensate samples using reduced graphene oxide

A Gholizadeh, K Black, H Kipen, R Laumbach, A Gow… – RSC …, 2022 – pubs.rsc.org

… using an RTube™ (Respiratory Research, Inc.) and a Jaeger EcoScreen. With the RTube, …
The condensate was partitioned and either analyzed immediately or frozen for the storage …

The cytokine level in exhaled breath condensate and cytokine genes polymorphism in children with bronchial asthma

MA Malinchik, NN Gorbacheva, VD Belenjuk… – Siberian Medical …, 2022 – smr.krasgmu.ru

… Сбор КВВ осуществляли с помощью прибора RTube Exhaler Breath Condensate Collector.
Концентрацию цитокинов в нативных образцах КВВ определяли с помощью системы …

Metabolomic profiling of exhaled breath condensate for the diagnosis of pulmonary aspergillosis

S Wei, Y Chen, Y Shi – Frontiers in Cellular and Infection Microbiology, 2022 – frontiersin.org

… The cooling sleeve is necessary for efficient condensate collection. Usually stored in a … This
unique feature allows for easy integration of the RTube into existing studies and allows large …

Weighted Gene Co-Expression Network Analysis on Proteomics of Exhaled Breath Condensate Based on Data-Independent Acquisition.

MA Lin, SUN Dongxiao, Z Huajun… – Journal of East China …, 2022 – search.ebscohost.com

… 呼出气采集装置为 RTube,全程佩戴鼻夹. 1.3 样品制备 … Abstract: Exhaled breath condensate
(EBC) is a kind of respiratory lining fluid, which is easy to collect and noninvasive. EBC is …

A pilot study of total personal exposure to volatile organic compounds among Hispanic female domestic cleaners

K Oyer-Peterson… – … of occupational and …, 2022 – Taylor & Francis

… the badges and provided blood and exhaled breath condensate (EBC) samples. From the …
RTube containing the EBC specimen was labeled only with the woman’s study id. The RTube …

EBC-SURE (exhaled breath condensate-scanning using rapid electro analytics): A non-faradaic and non-invasive electrochemical assay to screen for pro …

A Bhide, M Pali, S Muthukumar, S Prasad – Biosensors and Bioelectronics, 2022 – Elsevier

The innovation of this work lies in the trace detection of inflammatory biomarkers (IL-6, hs-CRP)
in human exhaled breath condensate on the developed EBC-SURE platform as a point-…

The Utility of Cell-free DNA in Exhaled Breath Condensate in the Detection of Lung Cancer Somatic Mutations

R Smyth – 2022 – repository.rcsi.com

… the utility of exhaled breath condensate to detect the EGFR-… the utility of exhaled breath
condensate to detect spatial genomic … the utility of exhaled breath condensate to detect the EGFR-…

Physical training reduces chronic airway inflammation and mediators of remodeling in asthma

R Moraes-Ferreira, MAR Brandao-Rangel… – … Medicine and Cellular …, 2022 – hindawi.com

… same day as the air-condensate collection and assessment of lung function and mechanics.
… Exhaled breath condensate collection was performed through the tube RTube (Respiratory …

The use of Exhaled Breath Condensate (EBC) in the Identification of Driver Mutations in Lung Cancer and SARS-CoV-2 viral RNA in Covid-19

D Ryan – 2022 – repository.rcsi.com

… Schematic of study participants and exclusion criteria for study 1 (Investigation of the utility
of exhaled breath condensate (EBC) to detect lung cancer specific driver mutations in patients …

Recent advances in exhaled breath sample preparation technologies for drug of abuse detection

F Xu, J Zhou, H Yang, L Chen, J Zhong, Y Peng… – TrAC Trends in …, 2022 – Elsevier

… This review details EB sampling devices such as exhaled breath condensate (EBC) devices,
EB … The well-known brand of pre-cooling device is Rtube, which can be easily operated by …

Exhaled Eicosanoid Metabolomics Suggest Oxidized Lipids/Eicosanoids Are Detectable in Lung Cancer Cases

SD Spivack, M Shi, A Sadoughi, C Shah… – C68. LUNG CANCER …, 2022 – atsjournals.org

… for assessing an eicosanoid signature in exhaled breath condensate (EBC), and are … ∼15min
of tidal breathing to 1.0ml volume in the RTube from the average clinical subject. The triple …

Annotating a protein list identified by LC-MS/MS experiments

V Loux, F Combes, D Christiany, Y Vandenbrouck – 2022 – galaxyproject.github.io

… Samples were obtained non-invasively by condensation of exhaled air that contains … As
EBC samples are obtained from air exhaled through the oral cavity, and even though the RTube …

Application of Modern Microcolumn Separation Methods Coupled to Mass Spectrometry for Analysis of Non-Invasive Biological Samples

V DOSEDĚLOVÁ – is.muni.cz

… Saliva and exhaled breath condensate (EBC) are attractive biological fluids in clinical …
The performance of the novel sampler was compared with the RTube™ device and our simple …

Aerobic training reduces chronic airway inflammation and mediators of remodeling in asthma

R Moraes-Ferreira, MAR Brandao-Rangel… – Available at SSRN … – papers.ssrn.com

… On the first day, the following evaluations were performed: (i) Exhaled breath condensate
collection through the tube RTube (Respiratory Research, USA), in which the patient breathed …

Role of breath biopsy in COVID-19

JK Shekhawat, M Banerjee – The Journal of Applied Laboratory …, 2022 – academic.oup.com

… Exhaled breath aerosols (EBAs) and exhaled breath condensate (EBC) are a potential …
There are various methods for collection of EBC from breath such as the RTube kit, TURBO-…

Analysis of Endogenous Metabolites in Human Matrices

W Struck-Lewicka, S Macioszek, M Artymowicz… – Handbook of …, 2022 – Springer

… a condensate (exhaled breath condensate [EBC]) by using dedicated devices such as Medivac
Turbo DECCS or RTube. … The condensate contains volatile compounds and nonvolatile …

JK Shekhawat, M Banerjee – The Journal of Applied Laboratory …, 2022 – europepmc.org

… There are various methods for collection of EBC from breath such as the RTube kit, TURBO-…
Study of exhaled breath condensate sample preparation for metabolomics analysis by LC–…

Arginina i jej analogi jako nowe biomarkery oznaczane w surowicy i kondensacie wydychanego powietrza w celu rozpoznawania i monitorowania przebiegu astmy …

J Połomska – 2022 – ppm.umw.edu.pl

… Aims Exhaled breath condensate is a potential source of … in serum and exhaled breath
condensate and compare them with … exhaled breath condensate collection using a RTube device. …

Уровень цитокинов в конденсате выдыхаемого воздуха и полиморфизм генов цитокинов при бронхиальной астме у детей

МА Малинчик, НН Горбачева… – Сибирское …, 2022 – cyberleninka.ru

… Сбор КВВ осуществляли с помощью прибора RTube Exhaler Breath Condensate Collector.
Концентрацию цитокинов в нативных образцах КВВ определяли с помощью системы …

2021

Exhaled breath condensate—a non-invasive approach for diagnostic methods in asthma

J Połomska, K Bar, B Sozańska – Journal of Clinical Medicine, 2021 – mdpi.com

… RTube breath condensate collection system differs significantly from the device described
above. RTube … system which is very similar to RTube and requires a cooled aluminum sleeve. …

Extracellular vesicle-derived microbiome obtained from exhaled breath condensate in patients with asthma

J An, A McDowell, YK Kim, TB Kim – Annals of Allergy, Asthma & …, 2021 – annallergy.org

The EBC samples were collected using RTube (Respiratory Research, Austin, Texas). EVs
were isolated from the EBC and analyzed. The extracted 16S recombinant DNA was …

Use of exhaled breath condensate (EBC) in the diagnosis of SARS-COV-2 (COVID-19)

DJ Ryan, S Toomey, SF Madden, M Casey… – Thorax, 2021 – thorax.bmj.com

False negatives from nasopharyngeal swabs (NPS) using reverse transcriptase PCR (RT-PCR)
in SARS-CoV-2 are high. Exhaled breath condensate (EBC) contains lower respiratory …

Sampling and Condensation of Exhaled Breath Air for the Monitoring of Viral Load and Lung Diseases

A Gesualdo – 2021 – webthesis.biblio.polito.it

… -35C [XV]; • Modified RTube™ EBC collection apparatus: is a researchbuilt device that consist
of an EcoVent attached to the air intake end of the RTube™, connected to HEPA filter and …

Putative biomarkers for acute pulmonary embolism in exhaled breath condensate

IL Gade, JG Schultz, RF Brøndum, B Kjærgaard… – Journal of Clinical …, 2021 – mdpi.com

… the proteome of the exhaled breath condensate (EBC) in a … The Rtube was inserted between
the expiratory limb of the Y-… The Rtube was inserted between the expiratory limb of the Y-…

Exhaled breath condensate in acute pulmonary embolism; a porcine study of effect of condensing temperature and feasibility of protein analysis by mass spectrometry

IL Gade, JG Schultz, LJ Cehofski… – Journal of Breath …, 2021 – iopscience.iop.org

The search for diagnostic biomarkers for pulmonary embolism (PE) has mainly been focused
on blood samples. Exhaled breath condensate (EBC) is a possible source for biomarkers …

Prediction of potential passive exposure from commercial electronic nicotine delivery systems using exhaled breath analysis and computational fluid dynamic …

MJ Oldham, PC Bailey, N Castro, Q Lang… – Journal of Breath …, 2021 – iopscience.iop.org

… Exhaled breath condensate from the RTube™ and filters were extracted for gas-chromatograph/mass
spectrometer (GC/MS) analysis. The concentrations of nicotine, propylene glycol, …

An Exhaled microRNA Panel Interrogated for Lung Cancer Case-Control Discrimination

M Shi, W Han, O Loudig, CD Shah, JB Dobkin, S Keller… – 2021 – researchsquare.com

… Breath condensate (EBC), per standard protocol. The essentials of the simple RTube® device
… a panel of 25 microRNAs in exhaled breath condensate using our RNA-speci c qualitative …

Employment of Computational Analysis to Reduces Electric Energy Consumption of an Ammonia Refrigeration System at a Peak Time

DB de Aguiar – Revista Interdisciplinar de Pesquisa em …, 2021 – periodicos.unb.br

… Rtotal in function of the tube thermal resistance Rtube, of contact Rcont, of incrustations …
real condensation capacity and the required capacity should be in the condensation temperature …

Nanotechnology-based strategies for effective and rapid detection of SARS-CoV-2

KL Moabelo, DR Martin, AO Fadaka, NRS Sibuyi… – Materials, 2021 – mdpi.com

… This concept was validated by using exhaled breath condensate (EBC) collected in RTube
condensers or face masks to detect SARS-CoV-2 genes (S, E, N, ORF1ab) [135]. The EBC …

The Differences in the Levels of Oxidative Status Marker and Soluble CD95 in Patients with Moderate to Severe COPD during an Exacerbation and a Stable …

S Soodaeva, N Kubysheva, I Klimanov… – … medicine and cellular …, 2021 – hindawi.com

… as sCD95 concentration in blood and exhaled breath condensate (EBC). The relationship
… EBC was collected using the RTube and following the guidelines for EBC by the ERS/ATS …

The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD

MP Ween, JB White, HB Tran, V Mukaro, C Jones… – Scientific reports, 2021 – nature.com

… Bronchoalveolar lavage and exhaled breath condensate were collected … condensate (EBC)
was collected using a commercial EBC collector as per manufacturer’s instructions (RTube; …

Exhaled biomarkers in acute asthma.

A Peel – 2021 – ueaeprints.uea.ac.uk

… in exhaled breath condensate and exhaled breath VOC in adult asthma were conducted. …
Figure 8 – The RTube: stock image of the device in use ……………………………………………… 105 …

The health effects of wearing facemasks on cardiopulmonary system of healthy young adults: a double-blinded, randomized crossover trial

M Jiang, X Meng, L Qi, X Hu, R Xu, M Yan, Y Shi… – International Journal of …, 2021 – Elsevier

… Exhaled breath condensate (EBC) was collected at all the four visits by using a
commercially available device from RTube™ (Respiratory Research, Inc., US) following the …

Caracterização composicional e mineralógica de amostras de condensado do ar exalado por lapidários de Corinto-MG

MS Silva – 2021 – monografias.ufop.br

… (EBCs/Exhaled Breath Condensate) por lapidários de Corinto … internamente um tubo plástico
(RTubes®/ Respiratory Research … De acordo com a fabricante dos RTubes®, esse tipo de …

2020

Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate

CM Wu, A Adetona, C Song, L Naeher… – … of environmental & …, 2020 – Taylor & Francis

… (non-burn days) using RTube TM breath condensate collection device (Respiratory Research,
… The RTube TM was stored in containers with dry ice immediately after the collection and …

Early diagnosis and screening in lung cancer

C Cainap, LA Pop, O Balacescu… – American Journal of …, 2020 – ncbi.nlm.nih.gov

… condensate analysis and specific genomic approaches. … use EcoScreen, TuboDECCS,
RTube, ANACON condenser is … also studies that used the Rtube condensers and still manage to …

Does exposure to inflammatory particles modify the pattern of anion in exhaled breath condensate?

JJ Sauvain, JL Edmé, P Wild, G Suarez… – Journal of breath …, 2020 – iopscience.iop.org

… Finally, we verified the possible contribution to the anion concentration from RTubes ® by
adding 2 ml of MiliQ water to each consumable, and shaking for at least 2 min. The stability of …

Clinical Application of Micrornas in Exhaled Breath Condensate and Bronchial Brushings as Early Diagnostic Biomarkers for Lung Cancer

BR Pattnaik, S Chakraborty, P Bajpai, J Tak… – B110. IMAGING AND …, 2020 – atsjournals.org

… miRNA signatures in the exhaled breath condensate (EBC) were found useful for early …
collected from 20 NSCLC patients, using RTubes. miRNA isolation followed by cDNA preparation …

Detection of epidermal growth factor receptor mutations in exhaled breath condensate using droplet digital polymerase chain reaction

K Nishii, K Ohashi, T Tamura… – Oncology …, 2020 – spandidos-publications.com

… The current study assessed the feasibility of testing exhaled breath condensate (EBC) for …
A total of 21 EBC samples were collected using the RTube™ method and EGFR mutations (…

Safety and Yield of Exhaled Breath Condensate Analysis in Acutely Ill, Mechanically Ventilated Infants with RSV Bronchiolitis

R Siddaiah, D Kitch, M Davies, H Rao, B Sankoorikal… – academia.edu

… The breath condensate was then aspirated from the RTube and aliquoted immediately to
be frozen at -80oC until processing. For mass spectrometry, breath condensates were …

Reference ranges of 8-isoprostane concentrations in exhaled breath condensate (EBC): a systematic review and meta-analysis

Y Shoman, P Wild, M Hemmendinger, M Graille… – International journal of …, 2020 – mdpi.com

… The difference between Ecoscreen and Rtube may be due to the … RTube is made from
polypropylene and needs shorter collection time compared to Ecoscreen. However, RTube …

Measurement of short-chain fatty acids in respiratory samples: keep your assay above the water line

M Yue, JH Kim, CR Evans, M Kachman… – American journal of …, 2020 – atsjournals.org

… On the day of study, EBC (RTube breath condensate collection device; Respiratory Research)
was acquired in accordance with the manufacturer’s instructions and American Thoracic …

A randomized, controlled, pilot study of CPAP for patients with chronic cough and obstructive sleep apnea

KM Sundar, AM Willis, S Smith, N Hu, JP Kitt, SS Birring – Lung, 2020 – Springer

… Exhaled breath condensate (EBC) was obtained using the RTube™ breath condensate
collection … Airway inflammation has been demonstrated in exhaled breath condensates of OSA …

Soluble interleukin-2 receptor in exhaled breath condensate in pulmonary sarcoidosis: a cross-sectional pilot study

DL Terrington, JW Kim, G Ravenhill… – Journal of Breath …, 2020 – iopscience.iop.org

… Paired serum and exhaled breath condensate samples were collected … condensate was
collected in accordance with current clinical guidelines and recommendations using an RTube …

Metabolomics of exhaled breath condensate by nuclear magnetic resonance spectroscopy and mass spectrometry: a methodological approach

M Maniscalco, A Cutignano, D Paris… – Current Medicinal …, 2020 – ingentaconnect.com

… The most used commercial condensers are EcoScreen, RTube and TURBO-DECCS, which
… In particular, condensation of exhaled air is achieved at average temperatures of 4 C (RTube

Exhaled breath condensate and aerosol

MD Davis – Breathborne biomarkers and the human volatilome, 2020 – Elsevier

… that is cooler than its temperature, exhaled breath condensate (EBC) forms. This fluid contains
… This diagram is not to scale; it has been estimated that the condensate circle represents …

Exhaled breath condensate: a non-invasive source for tracking of genetic and epigenetic alterations in lung diseases

S Kazeminasab, B Emamalizadeh… – Pharmaceutical …, 2020 – ps.tbzmed.ac.ir

… Condensation of exhaled breath is a possible approach to measure and analysis of … In
addition, there are several commercial and lab-made sampling devices such as RTube™…

Characterization of exhaled breath condensate (EBC) non-exchangeable hydrogen functional types and lung function of wildland firefighters

J Nelson, MCG Chalbot, Z Pavicevic… – Journal of Breath …, 2020 – iopscience.iop.org

… The objective of this study was to identify changes in metabolic profile of exhaled breath
condensate (EBC) and lung function of firefighters exposed to wildfires smoke. A total of 29 …

Hyperpnoea-induced bronchoconstriction: Prevalence in athletes, novel measure of airway inflammation, & treatment with the prebiotic Bimuno …

R Needham – 2020 – search.proquest.com

… to sample collection and place over the RTubes condensing chamber with the thermal …
RTube condensing chamber surface temperature during a 10 minute exhaled breath condensate …

Airway Hydrogen Peroxide During a Naturalistic Period of Sustained Psychological Stress in Individuals With Asthma and Healthy Controls

C Werchan – 2020 – scholar.smu.edu

… condensate (Rtube device, Respiratory Research Inc, Austin, Texas). Lastly, PEF and
FEV1 values were obtained using a hand-held spirometer (AM2, Jaeger/Toennies) into which …

Critical relevance of stochastic effects on low-bacterial-biomass 16S rRNA gene analysis

JR Erb-Downward, NR Falkowski, JC D’Souza… – MBio, 2020 – Am Soc Microbiol

… ) fluid, and exhaled breath condensate (EBC) samples and … were obtained using the RTube
collection system from … -distilled water over a fresh RTube and collecting the water. Isolation …

Inflammation in children with neuromuscular disorders and sleep disordered breathing

F Trucco, E Carruthers, JC Davies, AK Simonds… – Sleep medicine, 2020 – Elsevier

… (serum) and airway (exhaled breath condensate, EBC) levels of … condensate (EBC) were
collected [13]. Children wore a nose-clip and breathed for 10 min at tidal volume into a RTube

Bioanalytical HPLC applications of in-tube solid phase microextraction: A two-decade overview

N Manousi, PD Tzanavaras, CK Zacharis – Molecules, 2020 – mdpi.com

… in human exhaled breath condensate. In comparison with the … Exhaled breath condensate
(EBC) is a biological fluid … A commercial device, the RTube TM , was utilized to collect the …

Smoke Inhalation, Lung Function, and Heart Rate in Wildland Firefighters

JR Nelson – 2020 – search.proquest.com

… fluid (ALF) and thus found in exhaled breath condensate (EBC) due to aerosolization. These
… the deep lung condensate onto the walls of a collection device, such as the RTube. Recently…

혈중 호염기구 수에 따른 성인 천식의 임상 양상 분석 및 호기 응축물 내 사이토카인과의 연관성 분석

심지수, 김민혜, 조영주 – Allergy, Asthma & Respiratory Disease, 2020 – aard.or.kr

Purpose Although basophils are major effector cells involved in asthma, their pathophysiological
role in asthma remains uncertain. In this study, we investigated the relationship …

2019

Noninvasive glucose detection in exhaled breath condensate

D Tankasala, JC Linnes – Translational Research, 2019 – Elsevier

… The current devices on the market for EBC collection, EcoScreen, and RTube, use different
materials for trapping and cooling exhaled breath condensate. The RTube consists of a …

cfDNA in exhaled breath condensate (EBC) and contamination by ambient air: toward volatile biopsies

A Koc, T Goksel, L Pelit, K Korba… – Journal of Breath …, 2019 – iopscience.iop.org

… Exhaled breath condensate (EBC), also called volatile condensate, is a biological matrix that
… [1] and commercial devices, such as the RTube breath condensate collector [2], EcoScreen …

P1. 11-11 initial discovery of exhaled small polar energetics-related metabolites by GC-MS for lung cancer risk assessment

S Spivack, MK Shi, D Patel, A Desai, J Dobkin… – Journal of Thoracic …, 2019 – jto.org

… molecules in exhaled breath condensate in EBC from lung cancer patients and controls. …
breath condensate (EBC) was collected non-invasively, using a handheld device (RTube) in …

Effect of Continuous Positive Airway Pressure (CPAP) Vs. Sham CPAP in Chronic Unexplained Cough: A Randomized Study (Interim Analysis)

K Sundar, A Willis, S Smith, H Fletcher… – … AND OTHER TOPICS, 2019 – atsjournals.org

… Additional tests administered included exhaled breath condensate (RTube, Respiratory
Research Inc.) and Leicester Cough Monitoring (LCM) at baseline, 6 weeks and 12 weeks. …

Proteome profiling of the exhaled breath condensate after long-term spaceflights

AS Kononikhin, AG Brzhozovskiy… – International Journal of …, 2019 – mdpi.com

… Exhaled breath condensate (EBC) can be considered as a valuable subject for monitoring
physiological changes and is more suitable for long-term storage than traditional monitoring …

Exhaled breath testing–a tool for the clinician and researcher

MD Davis, SJ Fowler, AJ Montpetit – Paediatric respiratory reviews, 2019 – Elsevier

Exhaled breath is a robust matrix of biomarkers divided between three fractions – gaseous
breath, volatile breath, and breath condensate. Breath is collected non-invasively through …

The role of microRNAs in chronic pseudomonas lung infection in Cystic fibrosis

K Fesen, P Silveyra, N Fuentes, M Nicoleau… – Respiratory …, 2019 – Elsevier

… We collected exhaled breath condensate (EBC) from 27 subjects and evaluated miRNA …
from the RTube and placed on a syringe-style plunger that collected the condensate as per …

A new hypothesis to investigate bioequivalence of pharmaceutical inhalation products

M Khoubnasabjafari, E Rahimpour, M Samini… – DARU Journal of …, 2019 – Springer

… (EB) or exhaled breath condensate (EBC) can … condensate. Three commercial available
equipments for EBC sampling are i) ECoscreen (Erich Jaeger, Hoechberg, Germany), ii) RTube

Capturing and storing exhaled breath for offline analysis

IR White, SJ Fowler – Breath analysis, 2019 – Elsevier

… [75] reported the use of a modified RTube sampler (a sampler routinely used to collect
exhaled breath condensate) to sample breath volatiles by SPME. Following this, Respiratory …

Early moments of BLEVE: From vessel opening to liquid flashing release

AM Birk, R Eyssette, F Heymes – Process Safety and Environmental …, 2019 – Elsevier

… condensation takes place in the region between the Mach shock and the edge of the jet
interface. The condensation … the lead shock is fully formed somewhere between R/Rtube = 7–9 …

Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries

KP Singh, G Lawyer, T Muthumalage… – ERJ open …, 2019 – Eur Respiratory Soc

… EBC samples were collected during tidal breathing for 10 min using an RTube collection …
Supporting the observations in our study, pro-inflammatory effects of e-cig condensate on …

Characterization of Toxic Metal Exposure from Electronic Cigarette Use

A Aherrera – 2019 – j10p-stage.library.jhu.edu

… in urine, saliva, and exhaled breath condensate (EBC) of study participants (… Exhaled breath
condensate (EBC) … study reported Cr and Ni in urine, saliva and exhaled breath condensate …

Low-flow domiciliary oxygen as a mechanism of ongoing oxidative stress

JM Stulce, C Biddle, C Vacchiano – Respiratory Care, 2019 – rc.rcjournal.com

… by the presence of IsoF in exhaled breath condensate (EBC). Data collection occurred at
Phelps … The EBC was collected from each study participant using the RTube collection device (…

Lung Cancer Biomarkers in Proximal Fluids

GD Dakubo, GD Dakubo – Cancer Biomarkers in Body Fluids: Biomarkers …, 2019 – Springer

… As the name indicates, EBC is a condensate of expired air … inspiration and also to prevent
condensation of ambient air in … cooled aluminum-condensing sleeve (RTube™). Custom-made …

Prevention and early detection for NSCLC: advances in thoracic oncology 2018

H Balata, KM Fong, LE Hendriks, S Lam… – Journal of Thoracic …, 2019 – Elsevier

… Noninvasive biomarkers such as breath volatile organic compounds (VOCs) and exhaled
breath condensate (EBC), consisting of both VOCs and non-VOCs, are interesting to evaluate …

Exhaled small, polar, energetics-related metabolites by GC-MS for lung cancer risk assessment

SD Spivack, M Shi, D Patel, A Desai… – C110. THE FUTURE …, 2019 – atsjournals.org

… condensate in EBC from lung cancer patients and non-cancer controls. Methods: Exhaled

2018

Brief report on the detection of the EGFR T790M mutation in exhaled breath condensate from lung cancer patients

RJ Smyth, SM Toomey, A Sartori, E O’Hanrahan… – Journal of Thoracic …, 2018 – Elsevier

… EBC was collected by using an RTube breath condensate collection device (Respiratory
Research, Inc., Austin, TX) with the cooling sleeve at –70C. Patients breathed into the RTube …

Exhaled breath condensate: an update

MD Davis, AJ Montpetit – Immunology and Allergy …, 2018 – immunology.theclinics.com

… RTube Respiratory Research, USA More total EBC collections performed using RTube than
other systems. Multiple collections can be performed concurrently. More common in North …

P2. 11-17 MicroRNAs in Exhaled Breath Condensate and Bronchial Brushings as Biomarkers for Early Diagnosis of Lung Cancer

B Pattnaik, S Chakraborty, P Bajpai, A Agrawal… – Journal of Thoracic …, 2018 – jto.org

… miRNA signatures in the exhaled breath condensate (EBC) that are … Condensate Collection:
Samples were collected from the suspected NSCLC patients during OPD by using RTube. …

Proteomic characterization of human exhaled breath condensate

M Lacombe, C Marie-Desvergne… – Journal of breath …, 2018 – iopscience.iop.org

… In this study, we performed an in-depth proteomics characterization of exhaled breath
condensate (EBC), a sample obtained non-invasively by condensation of exhaled air that contains …

Exhaled breath condensate nitrite in premature infants with bronchopulmonary dysplasia

E Yen, BI Weinberger, RJ Laumbach… – Journal of Neonatal …, 2018 – content.iospress.com

… 80C temperature, the RTube TM was encased in a … RTube TM was disconnected from the
ventilator circuit and immediately capped on both ends while maintained in the dry ice. RTubes …

Non-volatile compounds in exhaled breath condensate: review of methodological aspects

E Rahimpour, M Khoubnasabjafari… – Analytical and …, 2018 – Springer

… In the second subtype of RTube, instead of … the RTube chamber [19, 20]. Turbo-DECCS
(transportable unit for research on biomarkers obtained from disposable exhaled condensate …

Effect of temperature control on the metabolite content in exhaled breath condensate

KO Zamuruyev, E Borras, DR Pettit, AA Aksenov… – Analytica chimica …, 2018 – Elsevier

… the effect of the condensation temperature on the concentration of acetone in EBC with a
regular, passively-cooled, and a custom thermoelectric cooling setup made for RTube™. A …

Determination of thiocyanate in exhaled breath condensate

JD Chandler, H Horati, DI Walker, E Pagliano… – Free Radical Biology …, 2018 – Elsevier

… For EBC collection, donors breathed steadily for 10 min into an RTube (Respiratory
Research, Austin, TX, USA) with an insulated aluminum sleeve pre-cooled to − 80 C. The RTube …

Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and …

MAG Wallace, JD Pleil – Analytica Chimica Acta, 2018 – Elsevier

… dry ice (−80 C) in order to condense the aqueous fraction of the exhaled air, depending on
… EBC are the RTube, Turbodecss, and EcoScreen. The RTube is advantageous because it is …

Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in …

A Bhimji, A Bhaskaran, LG Singer, D Kumar… – Clinical Microbiology …, 2018 – Elsevier

Objectives Exhaled breath condensate (EBC) is a noninvasive means of sampling the airways
that has shown significant promise in the diagnosis of many disorders. There have been …

Analysis of Exhaled Breath Condensate pH in Asthma among Indian Population-A Pilot Study.

MS Tendolkar, A Athavale, J Nair, S Tirpude… – … OF CLINICAL AND …, 2018 – academia.edu

… EBC condensate level of leukotriene E4 is increased in asthma but is not … portable RTube
and non-portable EcoScreen. There is a poor correlation between EBC pH obtained by RTube …

Selective collection and condensation of exhaled breath for glucose detection

D Tankasala, GP Ng, MS Smith… – 2018 40th Annual …, 2018 – ieeexplore.ieee.org

… Commercially-available collection systems such as the RTube and … fraction of glucose can
be collected in the condensate. … The condensate collected from this device provides a robust …

Evaluation of a new method for the collection and measurement of 8-isoprostane in exhaled breath for future application in nanoparticle exposure biomonitoring

C Marie-Desvergne, M Dubosson… – Journal of Breath …, 2018 – iopscience.iop.org

… condensate appear promising to detect early respiratory effects in workers handling
nanomaterials. However, condensation … were evaluated and compared to the RTube (RT). …

Phenotyping of chronic obstructive pulmonary disease based on the integration of metabolomes and clinical characteristics

K Kilk, A Aug, A Ottas, U Soomets, S Altraja… – International journal of …, 2018 – mdpi.com

… profiling of peripheral blood and exhaled breath condensate (EBC) within the context of …
breath condensate (EBC) were collected from individuals using a single-use Rtube™ set (…

Older women exhibit greater airway 8-isoprostane responses to strenuous exercise compared with older men and younger controls

SP Kurti, SR Emerson, JR Smith… – Applied Physiology …, 2018 – cdnsciencepub.com

… into an RTube (Respiratory Research, Austin, Texas, USA), collecting ∼1.0–1.5 mL of
exhaled breath condensate sample. The samples were then plunged from the RTubes, aliquoted …

P2. 11-18 A Comprehensive Lung Cancer Screening Program: 5 Years in Review

A Plank, M Reiter, L Reagan, B Nemesure – Journal of Thoracic Oncology, 2018 – jto.org

… miRNA signatures in the exhaled breath condensate (EBC) that are … Condensate Collection:
Samples were collected from the suspected NSCLC patients during OPD by using RTube. …

Metabolomics as a Novel Diagnostic Approach for Asthma

B Fatemeh Nobakht, A Arefi Oskouie – Genomic Approach to Asthma, 2018 – Springer

… NMR-based metabolomics analysis of EBC showed condense … plastic RTubes and
plastic RTubes vs. TURBO-DECCS … to the glass RTube compared to plastic RTubes (approximately …

P1. 11-12 Interrogation of an Exhaled MicroRNA Panel for Lung Cancer Risk Assessment

S Spivack – Journal of Thoracic Oncology, 2018 – jto.org

… Exhaled breath condensate (EBC) contains airway lining fluid molecules, including nucleic
… EBC was collected non-invasively, using a handheld commercial RTube® device in a clinical …

Soluble HLA-I and HLA-II molecules are potential prognostic markers of progression of systemic and local inflammation in patients with COPD

N Kubysheva, S Soodaeva, V Novikov, T Eliseeva… – Disease …, 2018 – hindawi.com

… The exhaled breath condensate was collected within 20 minutes after rinsing the mouth
using the RTube system (Respiratory Research, Inc., USA). The serum and EBC were stored at …

Abstracts from the 11th International Symposium on Minimal Residual Disease, 3–5 May 2018, Montpellier, France

C Alix-Panabières, K Pantel – Clinical & Experimental Metastasis, 2018 – Springer

… sought to investigate the ability of exhaled breath condensate (EBC) to detect EGFR-T790M …
using the RTube with the cooling sleeve at − 70 C. Patients breathed into the RTube for 10 …

P1. 11-10 Optimizing Radiomics Features by Minimizing Boundary Effects and Normalizing with Opposite Lung Tissue Characteristics

S Seyyedi, J Mayo, S Atkar-Khattra, R Yuan… – Journal of Thoracic …, 2018 – jto.org

… Exhaled breath condensate (EBC) contains airway lining fluid molecules, including nucleic
… Method: EBC was collected non-invasively, using a handheld commercial RTube® device in …

OSAHS 手术前后呼出气冷凝液中瘦素检测的临床意义

梁伟英, 吴平安, 朱洪蕾, 邓意红, 赵丹芸, 关亚峰… – 新医学, 2018 – xinyixue.cn

… clinical significance of leptin in the exhaled breath condensate(EBC) in evaluating the severity
… EBC收集:根据Horva’th Ⅰ推荐的方法,采用购自美国Respiratory Research公司的Rtube EBC…

AVALIAÇÃO DE IDOSOS INSTITUCIONALIZADOS POR ESPIROMETRIA E CONDENSADO BRÔNQUICO DO AR EXALADO: EFEITOS DA EXPOSIÇÃO …

JLFB DA COSTA – 2018 – core.ac.uk

… Para a recolha do EBC foi utilizado o dispositivo descartável RTube® (Respiratory Research
… The elderly were evaluated through spirometry and exhaled bronchial condensate (EBC). …

2017

Exhaled breath condensate metabolome clusters for endotype discovery in asthma

A Sinha, K Desiraju, K Aggarwal, R Kutum… – Journal of translational …, 2017 – Springer

… condensate was collected using RTubes (Respiratory Research, Austin, Texas). RTubes are
… to collect the condensate without contamination. They were immediately stored at − 80 C. …

Correlation between tumor necrosis factor-α and interleukin-1β in exhaled breath condensate and pulmonary function

X Lin, Y Fan, X Wang, M Chi, X Li, X Zhang… – The American Journal of …, 2017 – Elsevier

… by using an Rtube condensate collector device (Model Austin, TX 78720; RTube starter kit;
… Approximately, 2 mL of condensate was collected and immediately stored at −80C. The …

Assessment of leukotriene E4 in exhaled breath condensate as a marker of inflammation and therapeutic effect in allergic rhinitis children

BO Kwak, YM Park – Allergy, Asthma & Respiratory Disease, 2017 – synapse.koreamed.org

… that the cysteinyl leukotriene (cysLT) of exhaled breath condensate (EBC) could be predictive
of … EBC samples were collected with RTube. Each parameter was checked at 0, 2, and 10 …

Determining the presence of asthma-related molecules and salivary contamination in exhaled breath condensate

C Cruickshank-Quinn, M Armstrong, R Powell… – Respiratory …, 2017 – Springer

… 1; RTubes were attached to the syringe pump as shown in … RTube device (58.4 – 98.9%)
compared to the plastic RTube … to the plastic RTube by ~60% compared to the glass RTube (Fig…

The novel detection of EGFR-T790M mutations in exhaled breath condensate.

R Smyth, S Toomey, A Sartori, EO Hanrahan, S Cuffe… – 2017 – ascopubs.org

… Exhaled breath condensate (EBC) is an easily collected sample and is known to harbour …
EBC samples were collected using the RTube device. Plasma was collected using standard …

Aspergillus Galactomannan Detection in Exhaled Breath Condensate for the Diagnosis of Invasive Aspergillosis in Lung Transplant Recipients

A Bhimji, A Bhaskaran, LG Singer, D Kumar… – The Journal of Heart …, 2017 – jhltonline.org

… Standardized EBC collection was performed using a refrigerated condenser (RTube), and
BAL was performed immediately thereafter. EBC was run as both diluted and neat. EBC GM …

… validation of nanoparticle tracking analysis to measure pulmonary nanoparticle content: the size distribution in exhaled breath condensate depends on occupational …

JJ Sauvain, G Suarez, JL Edmé… – Journal of breath …, 2017 – iopscience.iop.org

… Finally, we verified that the different RTubes ® and microtubes used contained no particles
by adding 2 and 0.6 ml of filtered water to each consumable, respectively, and shaking/…

Analytical methodologies for broad metabolite coverage of exhaled breath condensate

AA Aksenov, KO Zamuruyev, A Pasamontes… – … of Chromatography B, 2017 – Elsevier

… -spread use similar to the RTube®, a common … RTube®, the employed device uses a glass
condenser surface to enhance measurement of metabolites in exhaled breath condensate [32…

Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate

AM Peel, CJ Crossman-Barnes, J Tang… – Journal of Breath …, 2017 – iopscience.iop.org

… Of the four studies using the RTube, two reported a positive difference between groups of
which one was statistically significant. The condensing surface of the RTube is polypropylene …

Correlation analysis of surfactant protein A and surfactant protein D with lung function in exhaled breath condensate from lung cancer patients with and without COPD

X Lin, Z Wu, Y Fan, M Chi… – Molecular …, 2017 – spandidos-publications.com

… an RTube condenser (Model Austin TX 78720; RTube starter … The procedure lasted 10-15
min and 1-3 ml condensate was … The condensate was removed into cryovial and stored at ‑80…

Exhaled breath condensate acidification occurs during surgery for abdominal cancer

A Mahairidou, S Rodopoulou, I Tomos… – Anticancer …, 2017 – ar.iiarjournals.org

… of about 1.0-1.5 ml of condensate, in the ward while wearing … an adequate volume of
condensate we decided to increase the … -min period by inserting the RTube early into the …

EGEA collection: a biobank devoted to asthma and asthma-related phenotypes

R Nadif, E Bouzigon… – Open Journal …, 2017 – account.openbioresources.metajnl …

… condensate (EBC) collected with an RTube™ (Respiratory Research Inc., Charlottesville,
VA, USA) under standardized procedures. Exhaled fraction of nitric oxide (FeNO) was also …

The association of e-cigarette use with exposure to nickel and chromium: a preliminary study of non-invasive biomarkers

A Aherrera, P Olmedo, M Grau-Perez, S Tanda… – Environmental …, 2017 – Elsevier

… We collected urine, saliva, and exhaled breath condensate (EBC), data on e-cigarette use, …
system (RTube™, Respiratory Research Inc, Austin TX) for 10 min. The Rtube consists of a …

Mycoplasma pneumoniae and health outcomes in children with asthma

PR Wood, JC Kampschmidt, PH Dube… – Annals of Allergy …, 2017 – Elsevier

… We collected exhaled breath condensate (EBC) using the RTube (Respiratory Research,
Austin, Texas) and measured EBC pH with an Orion Ross Micro pH electrode (Thermo …

Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

M Andrianjafimasy, F Zerimech, Z Akiki… – European …, 2017 – Eur Respiratory Soc

… Exhaled breath condensate (EBC) was collected using an RTube according a standardised
method as previously described [22]. Briefly, the RTube was rinsed with deionised water and …

Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates

K Dierschke, C Isaxon, UBK Andersson… – International archives of …, 2017 – Springer

… breathes into the RTube which was cooled to –25 C. The condensate was then allocated
to … Leukotriene B4 in exhaled air condensate was analysed using commercial LT-B4 EIA kit …

Pharmacogenomics and Molecular Diagnostics

ER Banerjee, ER Banerjee – Perspectives in Translational Research in Life …, 2017 – Springer

… Due to its portable nature, RTube ® can be easily used in longitudinal studies where the …
collected from RTube and EcoScreen reported higher volumes of the condensate and detection …

Development of non-invasive point-of-care sampling and analysis of biological fluids

M Greguš – is.muni.cz

… to collect condensate from different depths of the bronchial system, so that the dead space
condensate (= condensate … Based on our calculations the cooled internal surface of RTube is …

Clinical risk factors for invasive aspergillosis in lung transplant recipients: results of an international cohort study

C Aguilar, B Hamandi, C Fegbeutel… – The Journal of Heart …, 2017 – jhltonline.org

… The ability to detect GM in exhaled breath condensate (EBC) would be significantly less …
Standardized EBC collection was performed using a refrigerated condenser (RTube), and BAL …

Effects of dietary nitrate on respiratory physiology at high altitude-Results from the Xtreme Alps study

AF Cumpstey, PJ Hennis, ET Gilbert-Kawai… – Nitric Oxide, 2017 – Elsevier

… for E NO and breath condensate levels from treatment-naïve … Graphs showing mean exhaled
NO and breath condensate … in exhaled NO and breath condensate nitrite in response to …

Post-prandial systemic 8-isoprostane increases after consumption of moderate and high-fat meals in insufficiently active males

SP Kurti, SR Emerson, SK Rosenkranz, CS Teeman… – Nutrition research, 2017 – Elsevier

… After 10 minutes of data collection, ~1.5 mL of condensate was collected and immediately
frozen at −60C in the RTubes and later analyzed in triplicate for exhaled 8-isoprostane with a …

Post-prandial systemic 8-isoprostane increases after consumption of moderate-and high-fat meals in insufficiently active males

CBJ EM, JR Smith, CA Harms – … of Lifestyle, Age, and Sex on …, 2017 – search.proquest.com

… ,~ 1.5 mL of condensate was collected and immediately frozen at-60 C in the RTubes …
Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. …

New strategies and challenges in lung proteomics and metabolomics. An official American Thoracic Society workshop report

RP Bowler, CH Wendt, MB Fessler… – Annals of the …, 2017 – atsjournals.org

… lung investigations include exhaled breath condensate and epithelial brushes or biopsies. …
breath condensate (60) Consider commercial equipment, such as Ecoscreen or RTube; …

Serum Sst2 Levels Predict Severe Exacerbation Of Asthma: A Potential Implication For Neutrophilic Asthma

M Watanabe, K Nakamoto, M Sada, T Inui… – A35. SEVERE …, 2017 – atsjournals.org

… assessed by obtaining exhaled breath condensate (EBC) using an RTube (Respiratory
Research), followed by measuring HO levels using 2 2 …

Electro de sit easure e ts oa heliu-ater plas a: co pari ge peri e tal results to a zero di e sio al odel

A ea Gils – pure.tue.nl

… conditions at which water condensates. The operating range … helium), water starts to condense
easily in the reactor and at … mean velocity of the gas, Rtube the radius of the tube and η(p…

Analytical methods to investigate occupational exposure to toxic elements and their species

EJ Leese – 2017 – search.proquest.com

… Therefore, the work in this thesis also evaluates exhaled breath condensate (EBC) for its …
86 The RTube is a portable device consisting of a disposable t-section containing a non-…

Способ забора конденсата выдыхаемого воздуха новорожденных, находящихся на искусственной вентиляции

АС Кононихин, НЛ Стародубцева, ВВ Чаговец… – 2017 – elibrary.ru

… a condensate collection system and an auxiliary measuring module to monitor the collection
parameters. The condensate … для взрослых пациентов трубки Rtube. При этом авторы не …

Vergleich von zwei Geräten und zwei Atemmustern bei der Gewinnung von exhaliertem Atemwegskondensat

EM Schober – 2017 – archiv.ub.uni-marburg.de

… Es konnte gezeigt werden, dass die beiden kommerziell erwerbbaren Geräte RTube™ und
… A simple method for estimating respiratory solute dilution in exhaled breath condensates“. …

소아 알레르기비염에서 호기호흡농축물 내의 류코트리엔 E4 를 이용한 치료 효과와 염증 평가

곽병옥, 박용민 – Allergy, Asthma & Respiratory Disease, 2017 – aard.or.kr

… Recent studies have shown that the cysteinyl leukotriene (cysLT) of exhaled breath condensate
(… EBC samples were collected with RTube. Each parameter was checked at 0, 2, and 10 …

Προγνωστική αξία του συμπυκνώματος εκπνεόμενου αέρα στη διεγχειρητική και μετεγχειρητική πορεία ασθενών

Α Μαχαιρίδου – 2017 – didaktorika.gr

… Διεγχειρητικά, η λήψη δείγματος πραγματοποιήθηκε με χρήση RTube το οποίο τοποθετήθηκε
στο εκπνευστικό σκέλος του αναπνευστήρα. Κατά τη διάρκεια της μηχανικής αναπνοής …

Значение растворимых молекул клеточной адгезии, метаболитов оксида азота, эндотелина-1 и их ассоциаций как маркеров прогрессирования воспаления …

НИ Кубышева, ЛБ Постникова… – Современные …, 2017 – cyberleninka.ru

… blood serum and exhaled breath condensate. Results. The … blood and in exhaled breath
condensate. For the patients with … полости с помощью системы RTube (Respiratory Research…

2016

Human breath metabolomics using an optimized non-invasive exhaled breath condensate sampler

KO Zamuruyev, AA Aksenov… – Journal of breath …, 2016 – iopscience.iop.org

… The RTube ™ starts condensation at −54 C and warms up to 0 C over a 10 min sampling
period which limits its collection time and sample volume; it collects a slush-like EBC sample …

Exhaled breath condensate for lung cancer protein analysis: a review of methods and biomarkers

SA Hayes, S Haefliger, B Harris… – Journal of breath …, 2016 – iopscience.iop.org

… , less commonly, a pre-cooled aluminium condensing sleeve (found in the RTube condensing
system). Condensation of EBC vapour can be achieved at temperatures of 4 C or lower [77…

Assessment of nanoparticles and metal exposure of airport workers using exhaled breath condensate

C Marie-Desvergne, M Dubosson, L Touri… – Journal of breath …, 2016 – iopscience.iop.org

… During the preparation, an RTube was kept apart every 50 RTubes so as to constitute blank
… EBC in comparison with blank RTubes. Indeed, for ten out of eleven blank RTubes, the DLS …

Correction: comparison of two devices and two breathing patterns for exhaled breath condensate sampling

EM Hüttmann, T Greulich, J Koepke, C Nell… – Plos one, 2016 – journals.plos.org

… We have shown that the RTube device provided higher sample volumes compared to the
ECoScreen Turbo. Furthermore, hyperventilation provided higher sample volumes compared …

Non‐invasive lung cancer diagnosis by detection of GATA6 and NKX21 isoforms in exhaled breath condensate

A Mehta, J Cordero, S Dobersch… – EMBO molecular …, 2016 – embopress.org

… condensate collection Exhaled breath condensate collection was performed using the RTube
… ://www.respiratoryresearch.com/products-rtube-how.htm) and following the guidelines for …

A method for the preservation and determination of welding fume nanoparticles in exhaled breath condensate

S Gschwind, H Graczyk, D Günther… – Environmental Science …, 2016 – pubs.rsc.org

Analysis of exhaled breath condensate (EBC) represents a non-invasive method for detecting
inhaled nanoparticles (NPs) associated with various occupational and environmental …

Methodological issues and possible clinical implications for exhaled breath condensate pH in asthma

A Bikov, I Horvath – Current Topics in Medicinal Chemistry, 2016 – ingentaconnect.com

… (Jaeger) and the polypropylene Rtube (Respiratory Research) devices. Higher pH values
were reported when EBC was collected with the EcoScreen than the Rtube device for neat [37, …

The effect of space flight on the protein composition of the exhaled breath condensate of cosmonauts

KY Fedorchenko, AM Ryabokon’, AS Kononikhin… – Russian chemical …, 2016 – Springer

As a part of development of medicine for extreme situations, we determined, for the first time,
the protein composition of the exhaled breath condensate (EBC) of cosmonauts before and …

Early diagnosis of lung cancer based on proteome analysis of exhaled breath condensate

KU Fedorchenko, AM Ryabokon… – Moscow University …, 2016 – Springer

… a portable RTube device according to previously published pro tocols [14]. Comparative
analysis of the protein lists that were obtained using the ECoScreen and RTube devices was …

1H NMR To Explore the Metabolome of Exhaled Breath Condensate in α1-Antitrypsin Deficient Patients: A Pilot Study

C Airoldi, C Ciaramelli, M Fumagalli… – Journal of Proteome …, 2016 – ACS Publications

… Exhaled breath condensate was collected using an RTube condensing kit (Respiratory …
exhaled breath to condense along the walls of the tube. The volume of condensate collected was …

Air Quality in Metal Industries: Exhaled Breath Condensate, a Tool for Noninvasive Evaluation of Air Pollution Exposure

T Pinheiro, SM Almeida, PM Félix, C Franco… – Comprehensive …, 2016 – Elsevier

… The RTube device is a disposable system cooled by a cooling sleeve. … , condensation
temperature and ventilation rate may influence the EBC volume, pH, droplet size and condensation

Enhancing asthma self‐management in rural school‐aged children: A randomized controlled trial

SD Horner, A Brown, SA Brown… – The Journal of Rural …, 2016 – Wiley Online Library

… The child was directed to breathe normally into the RTube mouthpiece for 6 minutes and this
yielded sufficient volume of condensate. The RTube was capped and placed in a cold chest …

Ability of device to collect bacteria from cough aerosols generated by adults with cystic fibrosis

DN Ku, SK Ku, B Helfman, NA McCarty, BJ Wolff… – …, 2016 – ncbi.nlm.nih.gov

… The RTube™ system is designed to collect from all exhaled breath that condenses 28 while
… RTube™ as only water condensate is intended to be collected. Exhaled breath condensate …

Metabolic signatures of pneumonia in critical care: a paradigm shift in diagnosis and therapeutic monitoring

D Antcliffe, AC Gordon, M Takata, GB Hanna – 2016 – core.ac.uk

… in the RTube™ exhaled breath condensate collection device … and placed on in the top of
the RTube™, figure 2.1. The … the RTube™ to allow an adequate amount of condensate to …

Ability of device to collect bacteria from cough aerosols generated by adults with cystic fibrosis [version 1; referees: 2 approved]

DN Ku, SK Ku, B Helfman, NA McCarty, BJ Wolff… – 2016 – academia.edu

… The RTube™ system is designed to collect from all exhaled breath that condenses28 while
… RTube™ as only water condensate is intended to be collected. Exhaled breath condensate …

Low-Flow Domiciliary Oxygen as a Mechanism of Ongoing Oxidative Stress in COPD Patients

JM Stulce – 2016 – search.proquest.com

… The exhaled breath condensate (EBC) of 52 individuals with COPD was evaluated for the
presence of IsoF. An active control group not receiving LFDO (n= 26) was compared to an …

Enhanced non-invasive respiratory sampling from bottlenose dolphins for breath metabolomics measurements

KO Zamuruyev, AA Aksenov, M Baird… – Journal of breath …, 2016 – iopscience.iop.org

… for reproducible collection of exhaled breath condensate from small cetaceans, such as …
A few commercial devices are available for human EBC collection such as the RTube ™ …

Cardiovascular and pulmonary health effects of air pollution-long term effects in Sweden and effects of wood smoke

L Stockfelt – 2016 – gupea.ub.gu.se

… A main reason for this was probably the method of collecting breath condensate, the RTube,
chosen for being transportable and practical in this study with a high number of participants …

Systemic inflammation and oxidative stress post‐lung resection: Effect of pretreatment with N‐acetylcysteine

AJ Bastin, N Davies, E Lim, GJ Quinlan… – …, 2016 – Wiley Online Library

… blood cell glutathione and exhaled breath condensate pH were measured pre- and …
condensate (EBC; 0.5 to 1 mL) was collected in a polypropylene tube with a one-way valve (Rtube, …

Electronic nose and exhaled breath NMR-based metabolomics applications in airways disease

G Santini, N Mores, A Penas… – Current topics in …, 2016 – ingentaconnect.com

… , which is called exhaled breath condensate (EBC). Breathomics … In the RTube®, breath
sample is collected into a disposable … [47] As it is portable, RTube can be used for on site EBC …

A review of analytical techniques and their application in disease diagnosis in breathomics and salivaomics research

DJ Beale, OAH Jones, AV Karpe, S Dayalan… – International journal of …, 2016 – mdpi.com

… device, namely the RTube™. The SPME … condensate analysis [70,71], suitable cleaning
procedures and data quality control procedures enable NMR analysis of breath condensate and …

Hışıltılı çocuklarda magnezyum düzeyi

FG Demirkan – acikbilim.yok.gov.tr

… condensate (p>0.05). Further studies are needed to demonstrate effects of magnesium levels
in exhaled breath condensate … YEH pH değerleri Rtube pH değerlerinden anlamlı olarak …

2015

Exhaled breath condensate: technical and diagnostic aspects

EM Konstantinidi, AS Lappas, AS Tzortzi… – The Scientific World …, 2015 – hindawi.com

… the 30-year progress of research on exhaled breath condensate in a disease-based approach.
… using Rtube, where the temperature of cooling chamber is increasing with condensation, …

Electrospun polystyrene/graphene nanofiber film as a novel adsorbent of thin film microextraction for extraction of aldehydes in human exhaled breath condensates

J Huang, H Deng, D Song, H Xu – Analytica chimica acta, 2015 – Elsevier

… Exhaled breath condensate (EBC) samples were collected by a commercially available
condenser (RTube™, Respiratory Research, Inc., USA). Morphology of the synthesized …

Exhaled breath condensate pepsin: potential noninvasive test for gastroesophageal reflux in COPD and bronchiectasis

AL Lee, BM Button, L Denehy, S Roberts… – Respiratory …, 2015 – rc.rcjournal.com

… During the 24-h study period, EBC was collected using RTubes, with the RTube sleeve …
consistent with the method of collection using the RTube. EBC pH was measured before freezing …

The use of exhaled breath condensate to assess surfactant dysfunction from chlorine gas exposure

CA Edwards – 2015 – search.proquest.com

… , acting as a syringe to pool the condensate near the top of the RTube for easysample
collection. At this time, there is a sample volume of 0.5-1.5mL ready for surfacetension analysis. …

Analysis of aldehydes in human exhaled breath condensates by in-tube SPME-HPLC

SL Wang, S Hu, H Xu – Analytica Chimica Acta, 2015 – Elsevier

… available handheld EBC collection system, RTube™ technique. Eight lung cancer patients
… collection tube inserted in the cooled aluminum sleeve RTube, typically yielding 0.5–2.0 mL …

Conductivity in exhaled breath condensate from subjects with emphysema and type ZZ alpha-1-antitrypsin deficiency

J Stolk, M Fumagalli, S Viglio… – COPD: Journal of Chronic …, 2015 – Taylor & Francis

… condensate was collected using an RTube kit (… condense along the walls of the tube.
Subjects were asked to breath in this device while wearing a nose clip. The volume of condensate …

Immunochemistry for high-throughput screening of human exhaled breath condensate (EBC) media: implementation of automated Quanterix SIMOA instrumentation

JD Pleil, MM Angrish, MC Madden – Journal of breath research, 2015 – iopscience.iop.org

… The sampling methodology was based on modified Rtube ™ methods (Respiratory … (www.respiratoryresearch.com/rtube/).
In our modification, the Rtube was chilled with dry ice and …

Exhaled breath condensate pH decreases following oral glucose tolerance test

A Bikov, J Pako, D Montvai, D Kovacs… – Journal of breath …, 2015 – iopscience.iop.org

… Exhaled breath condensate was collected for 10 min using a commercial device (Rtube, …
After collection, condensate fluid was aliquoted into 1.5 ml polypropylene Eppendorf …

Proteomic analysis of exhaled breath condensate for diagnosis of pathologies of the respiratory system

AS Kononikhin, KY Fedorchenko… – Biomeditsinskaya …, 2015 – pbmc.ibmc.msk.ru

… Конденсат выдыхаемого воздуха собирали с помощью специальной стандартизованной
аппаратуры EcoScreen и Rtube (“Respiratory Research, Inc.”, США) в соответствии с …

Analysis of inflammatory cytokines in human blood, breath condensate, and urine using a multiplex immunoassay platform

MA Stiegel, JD Pleil, JR Sobus, MK Morgan… – Biomarkers, 2015 – Taylor & Francis

… To characterize and interpret this inflammatory response, methodology was developed
for measuring a suite of 10 different cytokines in human blood, exhaled breath condensate (EBC)…

Exhaled breath condensate pH in lung cancer, the impact of clinical factors

A Bikov, Z Lazar, N Gyulai, M Szentkereszty… – Lung, 2015 – Springer

… breathing for 10 min (RTube, Respiratory research Inc., Charlottsville, VI, USA) wearing a
nose clip. The chilling tube was held at −80 C before condensate collection. Samples were …

Single‐breath analysis using a novel simple sampler and capillary electrophoresis with contactless conductometric detection

M Greguš, F Foret, P Kubáň – Electrophoresis, 2015 – Wiley Online Library

… condensate (EBC) is one of the most promising noninvasive liquid sample obtained by cooling
and condensation of … RTube sampler at the cooling temperature of −15C. The design of …

Blood, sweat, and tears: developing clinically relevant protein biosensors for integrated body fluid analysis

SR Corrie, JW Coffey, J Islam, KA Markey, MAF Kendall – Analyst, 2015 – pubs.rsc.org

… the gas 103 however analysis of the breath condensate is technically challenging. …
condensate (eg the RTube™ – a nebulizer that non-invasively captures expired breath condensate …

Adipokines and cysteinyl leukotrienes in the pathogenesis of asthma

MJ Coffey, B Torretti, P Mancuso – Journal of allergy, 2015 – hindawi.com

… Exhaled breath condensate (EBC) was collected with RTube to determine airway lining fluid
… median log LTB4 levels in exhaled breath condensate for nonobese asthmatics as 50 pg/mL…

EBCpH variability in healthy children

A Karakatsani, S Rodopoulou, E Samoli… – 2015 – Eur Respiratory Soc

… Exhaled breath condensate was collected in a standardized manner, using the RTube
system from 51 children, 10 years old, participating in the RESPOZE study that investigates the …

Nanoparticle exposure biomonitoring: exposure/effect indicator development approaches

C Marie-Desvergne, M Dubosson… – Journal of Physics …, 2015 – iopscience.iop.org

… as nasal secretions and the exhaled breath condensates, seems a promising approach for
… employees benefited from this type of RTube sampling. This sampling was associated with a …

Health surveillance study of workers who manufacture multi-walled carbon nanotubes

JS Lee, YC Choi, JH Shin, JH Lee, Y Lee, SY Park… – …, 2015 – Taylor & Francis

… The exhaled breath condensate was then collected during 10 min of oral tidal breathing
using an RTube™ collection kit (Respiratory Research Inc., Austin, TX), while wearing a nose …

Gratis Journal of Cancer Biology and Therapeutics

A Alnashwan, A Hakamy, B Gongol, A Alismail, M Horn… – 2015 – researchgate.net

… In this study, we measured exhaled breath condensate (EBC) levels of biomarkers …
Exhaled breath condensates were collected using the RTube™ (Respiratory Research, Inc., …

Measuring compounds in exhaled air to detect Alzheimer’s disease and Parkinson’s disease

JP Bach, M Gold, D Mengel, A Hattesohl, D Lubbe… – PloS one, 2015 – journals.plos.org

… Although we found Aβ in exhaled breath condensate from both AD and healthy controls, no
… of tidal breathing through a single-use disposable RTube device (Respiratory Research Inc., …

Plasma VEGF levels and their relation to right ventricular function in pulmonary hypertension

J Pako, A Bikov, K Karlocai, G Csosza… – Clinical and …, 2015 – Taylor & Francis

… Exhaled breath condensate was collected with a commercially available device (RTube, …
We found that breath condensate VEGF measurements are not suitable to analyse the …

Analyst RSC

SR Corrie, JW Coffey, J Islam, KA Markey, MAF Kendall – scholar.archive.org

… the gas103 however analysis of the breath condensate is technically challenging.To …
condensate (eg the RTube™ – a nebulizer that non-invasively captures expired breath condensate …

Metal–Organic Framework 199 Film as a Novel Adsorbent of Thin-Film Extraction

S Wang, X Wang, Y Ren, H Xu – Chromatographia, 2015 – Springer

… determination of aldehyde in human exhaled breath condensates of lung cancer patients
and healthy … EBC samples were collected with a commercially available condenser (RTube™, …

A cross-sectional study of exhaled carbon monoxide as a biomarker of recent household air pollution exposure

A Lee, TR Sanchez, MH Shahriar, M Eunus… – Environmental …, 2015 – Elsevier

… measured by exhaled breath condensate pH, and lung … into an R-Tube™ breath condensate
collection device (Respiratory … Following the EBC collection period, the Rtube was capped …

Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

C Oyeniran, JL Sturgill, NC Hait, WC Huang… – Journal of Allergy and …, 2015 – Elsevier

… breath condensates. … an RTube and cooling sleeve (Respiratory Research, Austin, Tex)
and from patients admitted to the intensive care unit with a history of asthma by using an RTube …

Increase in oxidative stress levels following welding fume inhalation: a controlled human exposure study

H Graczyk, N Lewinski, J Zhao, JJ Sauvain… – Particle and fibre …, 2015 – Springer

… condensate (… Rtube cooling sleeve that had been cooled to −25 C. Volunteers were asked
to wrap their lips around the breathing zone and to breathe normally for 10 min into the Rtube …

Effects of cigarette smoke on methacholine-and AMP-induced air trapping in asthmatics

L Prieto, J Palop, R Llusar, S Herrera… – Journal of …, 2015 – Taylor & Francis

… ) nitric oxide (NO) and exhaled breath condensate pH were measured in 68 adults (23 current
… [Citation13] were obtained using a frozen sampling syringe, whereas we used the RTube. …

Association of Lung Inflammatory Cells with Small Airways Function and Exhaled Breath Markers in Smokers–Is There a Specific Role for Mast Cells?

Y Nussbaumer-Ochsner, J Stolk, LF Ferraz da Silva… – Plos one, 2015 – journals.plos.org

… of exhaled breath condensate (EBC). Exhaled breath condensate samples were collected …
of tidal breathing through a single-use disposable RTube device (Respiratory Research, Inc., …

Blood pressure and same-day exposure to air pollution at school: associations with nano-sized to coarse PM in children

N Pieters, G Koppen, M Van Poppel… – Environmental …, 2015 – ehp.niehs.nih.gov

… inflammatory marker was measured in exhaled breath condensate (EBC), a relevant matrix
… an RTube™ sampling device (Respiratory Research Inc., Austin, TX, USA). The RTube™ …

A randomized clinical trial of ascorbic acid in open abdominal aortic aneurysm repair

MJ Duffy, CM O’Kane, M Stevenson, IS Young… – Intensive Care Medicine …, 2015 – Springer

… Exhaled Breath Condensate (EBC) pH as a measure of alveolar … an RTube™ (Respiratory
Research, Austin, TX, USA) as previously described [37]. Exhaled breath condensate pH was …

Протеомный анализ конденсата выдыхаемого воздуха в целях диагностики патологий дыхательной системы

АС Кононихин, КЮ Федорченко… – Биомедицинская …, 2015 – pbmc.ibmc.msk.ru

… специальной стандартизованной аппаратуры EcoScreen и Rtube (“Respiratory Research…

Využití separačních metod v analýze biomarkerů

BJ Hodáková – is.muni.cz

… condensate with a limit of detection below 0.2 nM. This is the first published method for the
determination of glutathione in the breath condensate by … iba najedno použitie a RTube™ stojí …

Facteurs prédictifs du rejet chronique chez le transplanté pulmonaire: Cohorte COLT

I Coordonnateur, PA Magnan – filetransfer.fr

… Les condensats d’air exhalé seront collectés dans un système RTube®, conformément
aux habitudes de suivi des patients transplantés pulmonaires de chaque centre …

2014

Exhaled breath condensate for proteomic biomarker discovery

SW Harshman, CC Grigsby, DK Ott – Chromatography, 2014 – mdpi.com

… the Ecoscreen and RTube [10]. All these sampling devices strive to condense humid breath,
without salivary contamination, into liquid or ice, based on the condensation temperature, …

Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis

SB Montesi, SK Mathai, LN Brenner… – BMC pulmonary …, 2014 – Springer

… EBC was collected using the handheld RTube™ exhaled breath condensate collector (Respiratory
Research, Inc.), according to the manufacturer’s instructions, and following the ATS/…

D31 NONINVASIVE ASSESSMENT OF LUNG DISEASE: The Relationship Of Arginine And Its Metaboites In Exhaled Breath Condensate To Lung Function

L Ayyar, J Hsu, F Jahoor, C Kao – American Journal of …, 2014 – search.proquest.com

… Collection of exhaled breath condensate (EBC) is a non-invasive method of accessing the
… breath condensate (EBC) was collected per ATS/ERS recommendations using the Rtube ® …

Study on the influence factors of exhaled breath condensate pH detection of asthma children

C Xu, N Li, X Lin, Y Chen, C Liu, Y Li… – Wei Sheng yan jiu …, 2014 – europepmc.org

… To explore influence factors of exhaled breath condensate (EBC) pH detection and establish
… EBC samples were collected using Rtube EBC collection system, and pH values were …

Airway drug pharmacokinetics via analysis of exhaled breath condensate

CR Esther Jr, RC Boucher, MR Johnson… – Pulmonary …, 2014 – Elsevier

… EBC was extracted from the RTube via the manufacturer’s instructions at stored at −80 C
until analysis. Serum was obtained through blood draws at predose and at 1 and 6 h post-dose …

Exhaled breath condensate pH does not discriminate asymptomatic gastroesophageal reflux or the response to lansoprazole treatment in children with poorly …

AM Fitzpatrick, JT Holbrook, CY Wei, MS Brown… – The Journal of Allergy …, 2014 – Elsevier

… Children were instructed to take tidal breaths for 10 minutes into a plastic tube that contained
a 1-way exhalation valve and chilled aluminum condensation tube (RTube; Respiratory …

Exhaled breath condensate as a matrix for combustion-based nanoparticle exposure and health effect evaluation

JJ Sauvain, MSS Hohl, P Wild, JA Pralong… – Journal of aerosol …, 2014 – liebertpub.com

… Before use, the RTube was thoroughly rinsed with ultrapure water and air-dried in a clean …
Up to 2 mL of condensate was collected. About 500 μL was used immediately to determine the …

Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs

A Fernandez-Bustamante, J Klawitter, JE Repine… – …, 2014 – pubs.asahq.org

… condensate samples were collected with an Rtube™ breath … This Rtube™ consists of a sterile
polypropylene collection … ) during the collection period to condense the breath at the inner …

Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial

M Shyamsundar, DF McAuley, MO Shields… – 2014 – journals.lww.com

… and intraoperative exhaled breath condensate pH; alveolar type 1 … Exhaled breath condensate
was collected by using RTube (… Exhaled breath condensate was collected from intubated …

Associations between indicators of nitrosative stress and levels of soluble HLA-I, CD95 molecules in patients with COPD

N Kubysheva, S Soodaeva, L Postnikova… – COPD: Journal of …, 2014 – Taylor & Francis

… ) in the serum of blood and exhaled breath condensate (EBC) in patients with exacerbation
of … The exhaled breath condensate was collected using an RTube (USA) system, within 20 …

Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city

B Linares Segovia, G Cortés Sandoval… – BMC Pulmonary …, 2014 – Springer

… condensate analysis Exhaled breath condensate collection was performed using the RTube
… The condensate samples were obtained at an average ambient temperature of 13C. The …

A mutated vitamin D receptor in hereditary vitamin D-resistant rickets prevents induction of bronchial hyperreactivity and inflammation

R Bar-Yoseph, L Bentur, A Goldbart… – The Journal of …, 2014 – academic.oup.com

… The HVDRR patients had different cytokine levels in their exhaled breath condensate (…
Exhaled breath condensate EBC samples were collected in RTubes (Respiratory Research, Inc) …

Exhaled nitric oxide, nitrite/nitrate levels, allergy, rhinitis and asthma in the EGEA study

R Nadif, M Rava, B Decoster… – European …, 2014 – Eur Respiratory Soc

… The interest in measuring biological markers in exhaled breath condensate (EBC) in …
Briefly, the RTube was rinsed with deionised water and dried thoroughly. Participants …

Laboratory and clinical acute effects of active and passive indoor group water-pipe (narghile) smoking

L Bentur, E Hellou, A Goldbart, G Pillar, E Monovich… – Chest, 2014 – Elsevier

… EBC samples were collected in RTubes (Respiratory Research) as previously described.6,
13, … and discussion of exhaled breath condensate parameters and revision of the manuscript. …

Metabolic profiling of lung disease

P Thomas, M Turner – 2014 – Future Medicine

… commercially (eg, RTube from COSMED, … condensate contains both hydrophobic and
hydrophilic nonvolatile species as well as volatile compounds that are retained in the condensate. …

Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children

S De Prins, F Marcucci, L Sensi, E Van de Mieroop… – Biomarkers, 2014 – Taylor & Francis

… Nasal eosinophil cationic protein (ECP) and exhaled breath condensate (EBC) markers (pH…
using an RTube™ sampling device (Respiratory Research, Inc., Austin, TX). The RTube™ …

Airway oxidative stress and inflammation markers in exhaled breath from children are linked with exposure to black carbon

S De Prins, E Dons, M Van Poppel, LI Panis… – Environment …, 2014 – Elsevier

… (IL)-1β were analyzed in exhaled breath condensate (EBC). EBC is a non-invasive way to …
an RTube™ sampling device (Respiratory Research, Inc., Austin, TX, USA). The RTube™ was …

Hosted by the Children’s National Medical Center November 2–5, 2013, Washington, DC

M Sharron, K Johnson – journals.lww.com

… Background: Exhaled breath condensate (EBC) has been used to detect oxidative injury
and … A cooled RTube TM with a one-way valve was placed in the exhalation tubing of the …

Rapid detection of Pseudomonas aeruginosa biomarkers in biological fluids using surface-enhanced Raman scattering

X Wu, J Chen, Y Zhao… – Smart Biomedical and …, 2014 – spiedigitallibrary.org

… A total of 22 clinical exhaled breath condensates (EBC) samples were obtained from … for
10 min through a mouth piece of the portable RTube condenser (Respiratory Research, Inc., …

Standardizing the collection and measurement of glucose in exhaled breath and its relationship to blood glucose concentrations

M Hamilton II – 2014 – search.proquest.com

… The body of this thesis focuses on the use of exhaled breath condensate (EBC) for use as
an … RTube is a single use, non-invasive EBC collection system. Using an RTube, the patient …

Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters

JA Sarnat, R Golan, R Greenwald, AU Raysoni… – Environmental …, 2014 – Elsevier

… EBC was collected during a tidal breathing protocol with the use of a standardized breath-condensate
collector which was stored at −80 C prior to sampling (RTube, Austin, T, USA). …

In vivo and ex vivo SPME: a low invasive sampling and sample preparation tool in clinical bioanalysis

B Bojko, J Pawliszyn – Bioanalysis, 2014 – Future Science

… the collection of breath condensate followed by HS-SPME analysis. There are many options
for breath sample collection, including polymer bags, Bio-VOC ® tube, RTubes ® , Teflon ® …

An Exposure Study Linking Environmental and Human Biological Parameter Measurements, with a Focus on Th1/Th2 Cytokine Expression

M Stiegel – 2014 – cdr.lib.unc.edu

… condensate samples were collected using a RTubeTM (Respiratory Research, Inc., Austin
Texas) exhaled breath condensate … The RTube was removed from the sleeve after collection …

呼気 NO, 呼気凝集液

勝沼俊雄, 赤司賢一, 渡辺雅子 – 日本小児アレルギー学会誌, 2014 – jstage.jst.go.jp

… and 8isoprostane in exhaled breath condensate of children with asthma exacerbations. …
Increased leukotrieneE4 in the exhaled breath condensate of children with mild asthma. Chest …

소아 천식 환아의 호기농축시료에서 염증매개물질 측정의 의의

한윤기, 박준영, 김미나, 김윤희, 박현빈, 김민정… – 2014 – ir.ymlib.yonsei.ac.kr

… Purpose:There has recently been increasing interest in the use of exhaled breath condensate
(EBC) as a simple noninvasive means for understanding the physiology of asthma. The …

Methodological and physiological aspects of exhaled breath analysis

A Bikov – 2014 – repo.lib.semmelweis.hu

… breathing, small droplets arise from the ALF and condense … into the forming condensate
fluid. However, exhaled breath … condensate was collected during tidal breathing using Rtube (…

2013

Exhaled breath condensate: determination of non-volatile compounds and their potential for clinical diagnosis and monitoring. A review

P Kubáň, F Foret – Analytica chimica acta, 2013 – Elsevier

… Collection efficiency, was similar with short collection times when RTube sleeve was cooled
… in RTube device. In an independent study, the temperature inside the RTube collection tube …

Characterization of a portable method for the collection of exhaled breath condensate and subsequent analysis of metal content

JR Fox, EW Spannhake, KK Macri, CM Torrey… – … Science: Processes & …, 2013 – pubs.rsc.org

… Using exhaled breath condensate (EBC) as a biological media for analysis of biomarkers
of … We incorporated the use of an Rtube with additional components as an assembly, and …

Exhaled breath condensate purines correlate with lung function in infants and preschoolers

K Patel, SD Davis, R Johnson… – Pediatric …, 2013 – Wiley Online Library

… RTube EBC collection device (Respiratory Research) to the exhalation port of the nSpire Infant
Pulmonary Laboratory, with the RTube … EBC samples were extracted from the RTube and …

Exhaled breath condensate in pediatric asthma: promising new advance or pouring cold water on a lot of hot air? A systematic review

PS Thomas, AJ Lowe, P Samarasinghe… – Pediatric …, 2013 – Wiley Online Library

… can be collected and measured as exhaled breath condensate (EBC).7 EBC is mainly water
vapor … One sample with an uncoated RTube and another with RTube coated with 1% bovine …

Relationship between nitrate concentration in exhaled breath condensate and indoor air quality-ENVIRH study

I Caires, P Martins, J Marques, J Belo… – … Congress-New Ways …, 2013 – repositorio.insa.pt

… (NO), namely nitrates (NO3-) in exhaled breath condensate (EBC), is a good biomarker of …
EBC were collected, using a disposable device (RTube), from a group of children in preschool …

Exhaled breath condensates as a source for biomarkers for characterization of inflammatory lung diseases

P Bajaj, FT Ishmael – 2013 – scirp.org

… The ECoScreen uses an electric cooler, while the Rtube … enhanced portability and simplicity
of the Rtube [5]. According to … collection of 1 – 3 ml of condensate [6]. The apparatus should …

Exhaled breath condensate adenosine tracks lung function changes in cystic fibrosis

CR Esther Jr, BM Olsen, FC Lin… – American Journal of …, 2013 – journals.physiology.org

… EBC was collected and processed using the RTube (Respiratory Research, Charlottesville,
VA) as previously described (15). Briefly, subjects exhaled through the RTube for 7 min …

Exhaled breath condensate eicosanoid levels associate with asthma and its severity

S Kazani, A Planaguma, E Ono, M Bonini… – Journal of allergy and …, 2013 – Elsevier

… EBC was collected once from each enrolled study participant by using recommended
methods with an RTube (Respiratory Research, Austin, Tex). Participants were required to …

Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women

N Eszes, A Bikov, Z Lázár, A Bohács… – Acta Obstetricia et …, 2013 – Wiley Online Library

… Condensate samples were collected for 10 min using a handheld device (RTube, … The
chiller tube was held at −80C before condensate collection. Samples were stored at −80C in …

Effect of a controlled diesel exhaust exposure on airway oxidative stress in humans: analysis of exhaled breath condensate

B Malouf – 2013 – open.library.ubc.ca

… was to characterize the effects of a controlled diesel exhaust (DE) exposure on airway
oxidative stress in humans by measuring two biomarkers of interest in exhaled breath condensate …

Exosome-enclosed microRNAs in exhaled breath hold potential for biomarker discovery in patients with pulmonary diseases

A Sinha, AK Yadav, S Chakraborty… – Journal of allergy and …, 2013 – jacionline.org

… Exhaled breath was collected with the RTube (Respiratory Research) over a 10-minute
protocol, as per recommendations. It was concentrated for 3 hours by using Eppendorf …

Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV-negative patients by use of the GeneXpert MTB/RIF assay

S Shenai, D Amisano, K Ronacher, M Kriel… – Journal of clinical …, 2013 – Am Soc Microbiol

… body fluids such as exhaled breath condensate (EBC), saliva, … EBC was collected using a
commercially available RTube … valve which permitted the condensate to accumulate within …

Articles in PresS. Am J Physiol Lung Cell Mol Physiol (January 25, 2013). doi: 10.1152/ajplung. 00344.2012

CR Esther Jr, BM Olsen, FC Lin, J Fine, RC Boucher – 2013 – journals.physiology.org

… use of exhaled breath 61 condensate (EBC) as an … the RTube (Respiratory Research, 103
Charlottesville, VA) as previously described (15). Briefly, subjects exhaled through the RTube …

A mobile instrumentation platform to distinguish airway disorders

M Schivo, F Seichter, AA Aksenov… – Journal of breath …, 2013 – iopscience.iop.org

… healthy controls using exhaled breath condensate (EBC). The … RTube’s™ portability and
ease of use. A sleeve cooled to between −40 C and −50 C by dry ice was placed over the RTube

Design and conduct of ‘Xtreme Alps’: a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high …

DS Martin, ET Gilbert-Kawai, PM Meale… – Contemporary Clinical …, 2013 – Elsevier

… Exhaled breath condensate was collected in a non-invasive manner by … (RTube®, Respiratory
Research, Inc., Charlottesville, VA, USA). Two 1 ml aliquots of exhaled breath condensate …

Environment and health in children day care centers

N Neuparth, AL Papoila, C Pedro… – … and health in …, 2013 – repositorio.ipsantarem.pt

… Airway inflammation markers (condensate pH and total nitrites/nitrates) were measured in
breath condensate collected during 15 minutes using an RTube (Respiratory Research Inc., …

Analytical challenges in breath analysis and its application to exposure monitoring

M Alonso Roura… – © TrAC Trends in …, 2013 – dugi-doc.udg.edu

… But, it has been found that conventional EBC-collection methods (eg, Rtube at -80ºC) yield
… aluminum tube maintained at 40–45ºC to prevent condensation of the water vapor [84]. The …

Le dépistage du futur du cancer broncho-pulmonaire: perspectives et mythes

G Zalcman, L Reviron-Rabec, S Brosseau… – Revue des Maladies …, 2013 – Elsevier

… Studies of exhaled condensates showed such materials were … par un système permettant
la condensation des gaz exhalés, par … Le système du RTube™ permet ainsi de recueillir ces …

Paludisme en zone d’hyperendémie: apport de la réponse cytokinique et transcriptomique

C Travaillé-Aubert – 2013 – theses.fr

… the quantity and composition of obtained condensates. Two devices with different properties
have been patented and widely commercialized: the RTube (Respiratory Research, Inc., …

Docosahexaenoic acid-derived anti-inflammatory mediators in sputum of adults with cystic fibrosis: clinical and therapeutic implications

E Teopompi – 2013 – repository.unipr.it

… Exhaled Condensate can be collected simply by asking a patient, even a quite young
child, to exhale into a cold tube during tidal breathing. The condensate contains a small (but …

2012

Metabolomic signatures in nuclear magnetic resonance spectra of exhaled breath condensate identify asthma

A Sinha, V Krishnan, T Sethi, S Roy… – European …, 2012 – Eur Respiratory Soc

… Exhaled breath condensate (EBC) holds promise as a … disposable collection system (Rtube;
Respiratory Research, … H-NMR spectra of water from RTube collection tubes (disposable …

Methodological aspects of exhaled breath condensate collection and analysis

P Rosias – Journal of Breath Research, 2012 – iopscience.iop.org

… system to cool and form exhaled breath condensate (EBC) [1–… particles and can be assessed
in breath condensate [1, 2]. A … The pre-cooled RTube condenser is highly sensitive to the …

Nuclear magnetic resonance-based metabolomics of exhaled breath condensate: methodological aspects

A Motta, D Paris, D Melck… – European …, 2012 – Eur Respiratory Soc

… For example, a warm-up during condensation is observed when RTube or Anacon are used
… biomarkers measured in EBC collected with RTube and Anacon condensers; although both …

Exhaled breath condensate—an overview

MD Davis, A Montpetit, J Hunt – … and allergy clinics of North America, 2012 – ncbi.nlm.nih.gov

… RTube Respiratory Research, USA More total EBC collections performed using RTube than
… requires optional cooling unit, otherwise condensation temperature is chosen by cooling …

Alpha-1 antitrypsin is elevated in exhaled breath condensate and serum in exacerbated COPD patients

AR Koczulla, S Noeske, C Herr, J Koepke, RA Jörres… – Respiratory …, 2012 – Elsevier

… Measurement of exhaled breath condensate (EBC) is a noninvasive method to investigate
… with exacerbations of COPD was collected with the RTube™ device. AAT from EBC and …

Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma

S Hussain, R Laumbach, J Coleman… – … of occupational and …, 2012 – journals.lww.com

… Nitrite in exhaled breath condensate was elevated immediately after diesel exposure (P
= … Exhaled breath condensate pH did not demonstrate any clear pattern of change after …

Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS/MS

M Fumagalli, F Ferrari, M Luisetti, J Stolk… – International journal of …, 2012 – mdpi.com

… Exhaled breath condensate was collected by using the RTube kit (Respiratory Research
Inc., Austin, TX, USA) according to ATS/ERS guidelines [21]. The volume of condensate …

Nitric oxide in the exhaled breath condensate of healthy volunteers collected with a reusable device

DA Vento, L ívia Arcêncio, AJ Rodrigues – Archivos de Bronconeumología …, 2012 – Elsevier

… The EcoScreen ® and Rtube ® devices are made with Teflon and aluminum, 19 respectively…
compared the EcoScreen ® and Rtube ® devices with devices made of silicone-coated …

Profile of eicosanoids in breath condensate in asthma and COPD

LG Fritscher, M Post, MT Rodrigues… – Journal of breath …, 2012 – iopscience.iop.org

… EBC was collected by using a commercial device specifically designed to collect breath
condensate that comes with a cooling sleeve that is stored in a freezer (RTube®, Respiratory …

Exhaled breath condensate in critically ill mechanically ventilated patients

O Roca, JR Masclans – Clinical Pulmonary Medicine, 2012 – journals.lww.com

… Rtube is a precooled device and is therefore highly sensitive to higher ambient temperatures…
temperature during collection achieved with Rtube produces more acidic EBC samples. …

Hydrogen peroxide in exhaled breath condensate in asthmatic children during acute exacerbation and after treatment

C Caffarelli, E Calcinai, L Rinaldi, C Povesi Dascola… – Respiration, 2012 – karger.com

… of fluid collected from two devices (Ecoscreen and RTube) has yielded conflicting results, and
… phase or during the condensation process in water, irrespectively of the devices used [44]. …

Molecular and microscopic analysis of bacteria and viruses in exhaled breath collected using a simple impaction and condensing method

Z Xu, F Shen, X Li, Y Wu, Q Chen, X Jie, M Yao – PloS one, 2012 – journals.plos.org

… Rtube (widely used EBC collection device) with that of throat swab method, showing detection
rates of 7% and 46.8% for the Rtube … of the exhaled breath condensate collection device …

Plasma and exhaled breath condensate nitrite–nitrate level in relation to environmental exposures in adults in the EGEA study

M Rava, R Varraso, B Decoster, H Huyvaert… – Nitric Oxide, 2012 – Elsevier

… EBC was collected with an RTube (TM) according to standardized methods. Briefly, the
RTube (TM) was rinsed with deionized water and dried thoroughly. Subjects breathed orally at …

Asthma randomized trial of indoor wood smoke (ARTIS): rationale and methods

CW Noonan, TJ Ward – Contemporary clinical trials, 2012 – Elsevier

… condensate (EBC) samples per winter were collected using an Rtube breath condensate …
over the outside of a disposable vertical condensation/collection tube and connected to two-…

Associations between nitric oxide synthase genes and exhaled NO-related phenotypes according to asthma status

E Bouzigon, F Monier, M Boussaha, N Le Moual… – PLoS …, 2012 – journals.plos.org

… Exhaled breath condensate (EBC) was collected according to a standardized method using
RTube™. Total nitrite-nitrate (NO 2 –NO 3 ) levels were measured by the Griess reaction [30]…

Non-invasive biomarkers of lung inflammation in smoking subjects

M Malerba, P Montuschi – Current medicinal chemistry, 2012 – ingentaconnect.com

… sputum supernatants and exhaled breath condensate (EBC) are … The RTube is a portable
condenser that consists of a … As it is portable, RTube makes it possible to collect EBC samples …

Relationship between exhaled nitric oxide and exposure to low-level environmental tobacco smoke in children with asthma on inhaled corticosteroids

E de la Riva-Velasco, S Krishnan, AJ Dozor – Journal of Asthma, 2012 – Taylor & Francis

… condensate (EBC) was collected according to the ERS/ATS guidelines (Citation39) with the
RTube… PH in expired breath condensate of patients with inflammatory airway diseases. Am J …

Methods for the Detection of S-Nitrosothiols and Nitric Oxide in Blood and Breath.

NR Crist – 2012 – deepblue.lib.umich.edu

… Figure 3.1 Schematic of exhaled breath condensate … In one study, the RTube system and
the EcoScreen condenser were … were significantly higher than the pH of the RTube samples.…

Óxido nítrico en el condensado de aire espirado de individuos voluntarios sanos recolectado a través de un dispositivo reutilizable

DA Vento, L Arcêncio, AJ Rodrigues – Archivos de Bronconeumología, 2012 – Elsevier

… device in order to sample exhaled breath condensate in healthy adult volunteers, and to …
compararon los dispositivos EcoScreen ® y Rtube ® con dispositivos manufacturados con …

Die Effekte der Augmentationstherapie auf systemische sowie pulmonale Inflammationsmarker beim hereditären alpha1-Antitrypsinmangel

ST Schmid – 2012 – archiv.ub.uni-marburg.de

… Stelle auf das Exhaled Breath Condensate (EBC) und die … zur Gewinnung von EBC sind der
RTube (in dieser Studie … von -5C, wohingegen der RTube auf -20C vorgekühlt wird und sich …

第 24 群 鼻副鼻腔基礎 2

清水猛史, 野中学 – 日本耳鼻咽喉科学会会報, 2012 – jstage.jst.go.jp

… [目的]呼気凝縮液(exhaled breath condensate ; EBC)は,安全で非侵襲的な気道炎症評価法
として期待されている.こ れまで各種の酸化ストレスマーカー,エイコサノイド等の分析結果が報告されて…

Finaal rapport

K Gudrun, CB De Prins Sofie, D Evi… – 2012 – archief.algemeen.omgeving …

… RTube geschoven. De kinderen ademden gedurende 15 min rustig door het mondstuk van
de RTube … Wanneer men dit voelde opkomen mocht de RTube uit de mond worden genomen…

P8 副鼻腔炎 Ⅱ・鼻腔生理

大越俊夫, 加瀬康弘 – 日本鼻科学会会誌, 2012 – jstage.jst.go.jp

… [目的]呼気凝縮液(exhaled breath condensate; EBC) は,安全で非侵襲的な気道炎症評価法
として期待されて いる.これまで各種の酸化ストレスマーカー,エイコサ ノイド等の分析結果が報告されて…

2011

Exhaled breath condensate sampling is not a new method for detection of respiratory viruses

L Houspie, S De Coster, E Keyaerts, P Narongsack… – Virology journal, 2011 – Springer

… In the fall and first half of the winter of 2009/2010, 32 condensates were collected from …
condensates were collected with the cooler chilled at -20C. For 13 out of 32 collections, the RTube

Evaluation of exhaled breath condensate pH as a biomarker for COPD

W MacNee, SI Rennard, JF Hunt, LD Edwards… – Respiratory …, 2011 – Elsevier

… John Hunt, MD: JH is a co-founder of Respiratory Research, Inc., which develops exhaled
breath assays and manufactures the RTubes used in this study. Respiratory Research has …

Comparison of two devices and two breathing patterns for exhaled breath condensate sampling

EM Hüttmann, T Greulich, A Hattesohl, S Schmid… – PloS one, 2011 – journals.plos.org

… In contrast, in our comparison of ECoScreen I and RTube the EBC pH values were not
significantly different for the two devices [13]. Variation of the coating material also seemed to …

Day To Day Variability In Feno, Exhaled Breath Condensate Ph And Fev1/FVC Among 9-10 Year Old Urban Children

F Hafeez, BB Obeng, T Li, J Cai, C Olivo… – C35. INSIGHTS INTO …, 2011 – atsjournals.org

… Rationale: Fractional exhaled NO (FeNO), exhaled breath condensate (EBC) pH and lung
… EBC was collected using RTubes and pH was measured after de-aeration. Pulmonary …

Comparison of two devices and two breathing patterns for exhaled breath condensate sampling

AR Koczulla, E Hüttmann, T Greulich, A Hattesohl… – 2011 – Eur Respiratory Soc

… Results: RTube provided a higher sample volume compared to the EcoScreen. Hyperventilation
yielded higher volumes than tidal breathing. Neither devices nor breathing patterns …

Detection of the EGFR mutation in exhaled breath condensate from a heavy smoker with squamous cell carcinoma of the lung

D Zhang, N Takigawa, N Ochi, Y Tanimoto, D Noujima… – Lung Cancer, 2011 – Elsevier

… We previously showed that measurement of exhaled breath condensate (EBC) biomarkers
was a … using exhaled breath condensate (EBC) has been explored in lung cancer patients [5]. …

Detection of microorganisms in exhaled breath condensate during acute exacerbations of COPD

T Zakharkina, AR KOCZULLA, O Mardanova… – …, 2011 – Wiley Online Library

… condensate was collected according to the published ERS guidelines. In short, EBC samples
were collected during 10 min of quiet breathing through a single-use disposable RTube …

A new approach to study exhaled proteins as potential biomarkers for asthma

K Bloemen, R Van Den Heuvel… – Clinical & …, 2011 – Wiley Online Library

… Recently, various studies reported on the analysis of exhaled breath condensate (EBC) in …
in an uncoated RTube. A second EBC sample was collected for 10 min breathing in an RTube …

Exhaled breath condensate in mechanically ventilated brain-injured patients with no lung injury or sepsis

I Korovesi, E Papadomichelakis… – The Journal of the …, 2011 – pubs.asahq.org

… The RTube is a portable device that uses an exhalation valve that also … condensation
chamber.20Collecting time for EBC was 20 min, producing approximately a 1-ml condensate …

Exhaled breath condensate in asthma: from bench to bedside

S Loukides, K Kontogianni, G Hillas… – Current medicinal …, 2011 – ingentaconnect.com

… Exhaled breath condensate (EBC) collection represents a rather appealing method that
can be used to conveniently and noninvasively collect a wide range of volatile and non-volatile …

The effect of different periods of argon deaeration on exhaled breath condensate pH

L Prieto, B Orosa, D Barato, J Marin – Journal of Asthma, 2011 – Taylor & Francis

Background. Exhaled breath condensate (EBC) pH has been considered as a biomarker of
airway inflammation in asthma. However, little information is available on the duration of …

Exhaled Breath Condensate Biomarkers of Airway Inflammation and Oxidative Stress in COPD

P Montuschi – Studies on Experimental Models, 2011 – Springer

… The RTube (Fig. 1b) consists of a disposable polypropylene tube that is connected to an …
As it is portable, the RTube is suitable for onsite collection of EBC samples. Generally, a 1-min …

Pro-oxidant iron in exhaled breath condensate: a potential excretory mechanism

S Mumby, KF Chung, JE McCreanor, ED Moloney… – Respiratory …, 2011 – Elsevier

… Therefore in the current study, we assessed whether exhaled breath condensate (EBC)
sampling could be utilised to assess levels of and catalytic potential of this extracellular pro-…

Reduced breath condensate pH in asymptomatic children with prior wheezing as a risk factor for asthma

M von Jagwitz, F Pessler, M Akmatov, J Li… – Journal of allergy and …, 2011 – Elsevier

… Feno), the pH of deaerated exhaled breath condensate pH (dEBC pH) was proposed as the
… with different methods, such as EcoScreen and Rtube.20, 21 Mean and median dEBC pH …

Non-invasive biomarkers applied in a case-control study

K Bloemen, R Van Den Heuvel, G Koppen, V Nelen… – 2011 – Eur Respiratory Soc

… Methods: Asthmatic (N=72) and healthy (N=67) children (6-12 years) donated exhaled
breath condensate (EBC; RTube) and exhaled gasses (Tedlar bag). Fractional exhaled nitric …

Exercise changes volatiles in exhaled breath assessed by an electronic nose

A Bikov, Z Lazar, K Schandl, B Antus… – Acta Physiologica …, 2011 – akjournals.com

… for the alkalization of the exhaled breath condensate (EBC) fluid following physical exercise.
… Exhaled breath condensate was collected with a commercially available condenser (RTube

Biomarkers of lung injury after one‐lung ventilation for lung resection

AJ Bastin, H Sato, SJ Davidson, GJ Quinlan… – …, 2011 – Wiley Online Library

… The objective of this study was to characterise the effect of lung resection and OLV on
proposed biomarkers of lung injury in exhaled breath condensate (EBC) and plasma. …

Discrimination between COPD patients with and without alpha 1‐antitrypsin deficiency using an electronic nose

ADM Hattesohl, RA JÖRres, H Dressel, S Schmid… – …, 2011 – Wiley Online Library

… Methods: Exhaled breath condensate and pure exhaled … Exhaled breath condensate and
pure exhaled breath were … a single-use disposable RTube device (Respiratory Research Inc., …

RESIDENTIAL WOOD SMOKE PM2.5 AND A BIOMARKER OF OXIDATIVE STRESS IN ASTHMATIC CHILDREN

M McNamara, E Semmens, T Ward… – ISEE Conference …, 2011 – ehp.niehs.nih.gov

… Background and Aims: Exhaled breath condensate (EBC) is a biofluid that can be analyzed
… EBC samples were collected using Rtubes (Respiratory Research) and were analyzed for 8-…

Elevated airway purines in COPD

CR Esther Jr, AL Lazaar, E Bordonali, B Qaqish… – Chest, 2011 – Elsevier

… labeled internal standards within an exhaled breath condensate (EBC) from a subject with
… dilution of airway secretions within the condensate. Two samples with AMP concentrations …

The Effect Of Augmentation Therapy On Systemic And Pulmonary Inflammation Markers In Alpha1-Antitrypsin Deficiency Patients

S Schmid, S Noeske, A Hattesohl… – … AND MODELS OF …, 2011 – atsjournals.org

… the blood and Exhaled Breath Condensate (EBC) and their immediate reaction on substitution
of AAT. Methods: EBC from all individuals was collected with the RTube device by gently …

Windsor, Ontario exposure assessment study: design and methods validation of personal, indoor, and outdoor air pollution monitoring

AJ Wheeler, X Xu, R Kulka, H You… – Journal of the Air & …, 2011 – Taylor & Francis

… , an exhaled breath condensate sample was collected using an RTube (Respiratory Research…
Approximately 1 mL of breath condensate was collected. The condensed breath was then …

Plasma VEGF correlates with right ventricular function in pulmonary hypertension

J Pako, A Bikov, K Karlocai, G Csosza, D Kovacs… – 2011 – Eur Respiratory Soc

… Aims: We aimed to evaluate the exhaled breath condensate (EBC), as an airway sampling
technique for VEGF detection in subjects with PH and to compare EBC and plasma VEGF …

INDOOR RISK FACTORS FOR CHILDHOOD RESPIRATORY DISEASES: DEVELOPMENT AND APPLICATION OF NON-INVASIVE BIOMARKERS “ANIMO”

G Schoeters, R Van Den Heuvel, K Bloemen… – belspo.be

… Exhaled breath condensate (EBC) … RTube (Respiratory Research, Inc). This allowed to
collect between 1 and 1.5 mL EBC. We analysed the collected volume, the pH of the condensate, …

Biomarkers Of Airway Inflammation In Asthmatic Children On Inhaled Corticosteroid Therapy Exposed To Low Levels Of Environmental Tobacco Smoke

E De La Riva-Velasco, S Krishnan… – C106. PEDIATRIC …, 2011 – atsjournals.org

… Exhaled breath condensate (EBC) was collected using the RTube technique, and tested
for pH and ammonia concentration. Thirty three subjects were enrolled, including twenty four …

Condensing exhaled breath into science

J Hunt – Chest, 2011 – journal.chestnet.org

… water condensation. These investigators used a dilution marker presented by Effros et al …
The products are RTube and Aeriflux. The company also manufacturers ALFA (airway lining …

Airway peroxidases catalyze nitration of the β2-agonist salbutamol and decrease its pharmacological activity

KJ Reszka, L Sallans, S Macha, K Brown… – … of Pharmacology and …, 2011 – ASPET

… a single-use disposable RTube collector (Respiratory Research, Inc… of exhaled breath
condensates from asthmatic patients who … metabolites, we pooled condensates from three different …

Airway Peroxidases Catalyze Nitration of the ß2-Agonist Salbutamol and Decrease Its Pharmacological Activity

KJ Reszka, L Sallans, S Macha, K Brown… – THE JOURNAL OF … – Citeseer

… of quiet breathing through a single-use disposable RTube collector (Respiratory Research,
Inc., … olites, we pooled condensates from three different subjects and analyzed it as a single …

Analysis of endogenous particles in exhaled air

AC Almstrand – 2011 – gupea.ub.gu.se

… particles and exhaled breath condensate. In parallel to … when particles grow during
condensation. The EBC contains … is a stationary system and the RTube (Respiratory Research), …

Exhaled breath analysis for diagnosis and phenotyping in obstructive lung diseases

B Ibrahim – 2011 – search.proquest.com

… (two involving exhaled gas and one involving breath condensate) were conducted, as well
as … In the exhaled breath condensate (EBC) study, similar data were collected in asthmatics …

The Airway Microbiotica in healthly State and chronic obstructive pulmonary Disease

T Zakharkina – 2011 – publikationen.sulb.uni-saarland.de

… The collection of exhaled breath condensate (EBC) allows one to noninvasively determine
parameters that are associated with physiological or disease processes [76]. In AECOPD, …

  1. Treatment strategies, systemic manifestations and biomarkers in airway diseases

P Strohner, A Staatz, A Schaefer, G Becher, D Sarrach… – ers-education.org

… Aims: We aimed to evaluate the exhaled breath condensate (EBC), as an airway sampling
technique for VEGF detection in subjects with PH and to compare EBC and plasma VEGF …

Atopy, Asthma And The Nitrite-Nitrate-No Pathway Among Adults From The Egea Study

M Rava, F Kauffmann, H Huyvaert… – C51. ASTHMA …, 2011 – atsjournals.org

… EBC was collected using RTube™. Total NO2-NO3 (converted nitrate plus nitrite, Griess
reaction) was expressed as µM in plasma and as µmol/µg in EBC (NO -NO divided by …

Desenvolvimento de um aparato para a coleta do condensado do exalado pulmonar visando a análise do óxido nítrico em indivíduos hígidos

DA Vento – 2011 – teses.usp.br

… cooling and condensation, termed exhaled breath condensate. … individuals using exhaled
breath condensate. Given this, it … Os aparatos comerciais EcoScreen e Rtube são produzidos …

Nachweis von Alpha-1-Antitrypsin in exhaliertem Atemwegskondensat

S Noeske – 2011 – archiv.ub.uni-marburg.de

… Das RTube™ ist ein austauschbares System und besteht aus einem Mundstück, das über
eine Einwegklappe mit einem Sammelrohr aus Kunststoff verbunden ist. Dieses wird von …

Παρακολούθηση της φλεγμονής των αεραγωγών σε ασθενείς με βρογχικό άσθμα και αλλεργική ρινίτιδα

Κ Τάνου – 2011 – ir.lib.uth.gr

… VEGF, TNF-alpha and 8-isoprostane levels in exhaled breath condensate and serum of
patients with lung cancer. Dalaveris E, Kerenidi T, Katsabeki-Katsafli A, Kiropoulos TS, Tanou K, …

Uloga pH kondenzata izdaha u procjeni učinaka profesionalne izloženosti organskoj prašini na dišni sustav [The role of EBC pH in the assessment of respiratory …

A Ljubičić Ćalušić – 2011 – medlib.mef.hr

… condensation nuclei counter) i laserskog spektrometra s visokom vremenskom rezolucijom
… dobivenih EcoScreen uređajem u odnosu na one dobivene RTube uređajem (61, 107), dok u …

Uloga pH kondenzata izdaha u procjeni učinaka profesionalne izloženosti organskoj prašini na dišni sustav

A Ljubičić Ćalušić – 2011 – repozitorij.unizg.hr

… condensation nuclei counter) i laserskog spektrometra s visokom vremenskom rezolucijom
… dobivenih EcoScreen uređajem u odnosu na one dobivene RTube uređajem (61, 107), dok u …

2010

Ambient temperature impacts on pH of exhaled breath condensate

AR Koczulla, S Noeske, C Herr, F Dette… – …, 2010 – Wiley Online Library

… Exhaled breath condensate samples were collected during 10 min of quiet breathing through
a single-use disposable RTube device (Respiratory Research, Inc., USA) using a nose clip…

Efficacy of two breath condensers

A Davidsson, B Schmekel – Journal of clinical laboratory …, 2010 – Wiley Online Library

… Volumes of condensates collected during 10min of condensation by ECoScreen or RTube,
… In contrast, significantly higher volumes of condensates were recovered by ECoScreen …

Total Nitrate/Nitrite levels in plasma and exhaled breath condensate: associations with age and smoking according to asthma among 1159 adults from the EGEA study

R Nadif, B Decoster, H Huyvaert, G Briand… – B47. ASTHMA …, 2010 – atsjournals.org

Methods–EBC was collected according to standardized method using RTube™. In plasma
and EBC, total NO2-NO3 (converted nitrate plus nitrite) was measured by using the Griess …

Isoprostanes-biomarkers of lipid peroxidation: their utility in evaluating oxidative stress and analysis

M Janicka, A Kot-Wasik, J Kot, J Namieśnik – International Journal of …, 2010 – mdpi.com

… As the subject breathes normally into the device, the RTube gathers breath condensate in
a … Measurements in EBC samples collected by RTube and ECoScreen are repeatable and …

An Electronic Nose Distinguishes The Exhaled Breath Condensates Obtained By Two Different Devices And Two Different Breath Patterns

S Noeske, A Hattesohl, R Jörres, T Greulich… – … AND AEROSOLS IN …, 2010 – atsjournals.org

… and distinguish the VOCs in exhaled breath condensate (EBC) of healthy subjects using two
different devices for obtaining EBC. The portable RTube® (Respiratory Research,USA) and …

Analysis By SELDI-TOF Of Exhaled Breath Condensate May Discriminate COPD From Healthy Subjects

M Fumagalli, D Capuano, J Stolk… – … AND LUNG DISEASE …, 2010 – atsjournals.org

… is currently increasing, in particular Exhaled Breath Condensate (EBC), a liquid phase that …
-TOF MS to EBCs collected with a RTube from 80 subjects grouped into four distinct groups ie …

Human breath analysis: methods for sample collection and reduction of localized background effects

AN Martin, GR Farquar, AD Jones, M Frank – Analytical and bioanalytical …, 2010 – Springer

… breath condensate at −80 C followed by passive SPME sampling of the collected condensate
Also in the current study, additional RTube™ modifications and methods of providing clean …

Exhaled breath condensate: adenosine, ATP and other purines

Z Lázár, G Vass, E Huszár, G Losonczy… – Horvath, JC de …, 2010 – researchgate.net

… , have also been detected in exhaled breath condensate (EBC) to aid diagnosis and follow-…
samples do not influence measurements in the condensate fluid. Recently, the simultaneous …

Levels of exhaled breath condensate pH and fractional exhaled nitric oxide in retired coal miners

JS Lee, JH Shin, JO Lee, KM Lee, JH Kim… – Toxicological …, 2010 – Springer

… Exhaled breath condensate was collected during oral tidal breathing using the Rtube …
The condensate was transferred from the collection tube into cryogenic vials and stored at −80 …

Adenosine triphosphate concentration of exhaled breath condensate in asthma

Z Lázár, L Cervenak, M Orosz, G Gálffy, ZI Komlósi… – Chest, 2010 – Elsevier

… Breath condensation has the potential to be applied in large-scale clinical studies and …
To estimate droplet dilution in the condensate fluid, measuring the concentrations of urea, total …

Establishing a functional relationship between the glucose concentrations in exhaled breath condensates and blood

AP Mohan – 2010 – search.proquest.com

… RTube® Rtube is another device used to collect and condense EBC into a small sealed and
stored chamber. When exhaling normally into the device the moisture in the exhaled breath …

Disease Markers in the Exhaled Breath Condensate of Infants and Preschoolers

KA Patel, SD Davis, R Johnson… – B56. MEASURING LUNG …, 2010 – atsjournals.org

… We hypothesized that development of methods to collect and measure inflammatory
biomarkers in exhaled breath condensate (EBC) could provide a less invasive method to assess …

Identification of intrinsic airway acidification in pulmonary tuberculosis

L Ngamtrakulpanit, Y Yu, A Adjei, G Amoah… – Global journal of …, 2010 – ncbi.nlm.nih.gov

… Exhaled breath condensate acidification reflects the presence … We collected exhaled
breath condensate, and assayed for … EBC was collected using the RTube system (Respiratory …

The role of purinergic system in airway diseases

Z Lázár – Citeseer

… The chiller tube of the RTube was held at -80ºC before condensate collection. EBC samples
were stored at -80ºC in DNA/RNA LoBind microcentrifuge tubes (Eppendorf AG; Hamburg, …

Biomarkers in asthma and allergic rhinitis

Z Diamant, JD Boot, E Mantzouranis, R Flohr… – Pulmonary …, 2010 – Elsevier

… have been measured in sputum and exhaled breath condensate (EBC) of both healthy controls
… higher compared to the RTube samples (1.8 ± 0.1 and 1.4 ± 0.1 mL, respectively) [109], …

Changes in exhaled nitric oxide and breath pH during fluticasone wean in asthma

L Liu, P Urban, JF Hunt, P Wilkinson, K Laning… – Respiration, 2010 – karger.com

… Breath condensate pH is low during acute asthma exacerbations and increases with
corticosteroid dosing [10]. However, the effect of systematic dose weaning on FENO and EBC pH is …

Mass spectrometric analysis of biomarkers and

AJ Ghio, JW Swenberg, RC Boucher, CR Esther Jr… – J. Biol. Chem, 2010 – academia.edu

… has not been previously observed with the RTube under supervised collections such as those
… that these are underrepresented within the condensate, a hypothesis consistent with our …

Application of non-invasive biomarkers in a birth cohort follow-up in relation to respiratory health outcome

K Bloemen, G Koppen, E Govarts, A Colles… – Biomarkers, 2010 – Taylor & Francis

… Recently, exhaled breath condensate (EBC), a fluid formed by cooling exhaled air, has …
The children exhaled about half of this through the device (RTube; Respiratory Research, Inc., …

Earth-air and earth-water heat exchanger design for ventilation systems in buildings

M De Paepe, C T’Joen… – International Heat …, 2010 – asmedigitalcollection.asme.org

… Secondly, because during summer operation condensation inside the tubes will occur, the
… Adding the thermal resistance of the tube wall (Rtube) is fairly straight forward (tube wall …

Chemically polymerized polypyrrole for on-chip concentration of volatile breath metabolites

N Strand, A Bhushan, M Schivo, NJ Kenyon… – Sensors and Actuators B …, 2010 – Elsevier

… These diced devices were inserted into the end of a commercial RTube™ breath collection
… one-way valves with an exhaled breath condensate (EBC) collection tube surrounding and …

Clinical applications of breath testing

KM Paschke, A Mashir, RA Dweik – F1000 medicine reports, 2010 – ncbi.nlm.nih.gov

… dissolved in aerosolized droplets in exhaled breath condensate (EBC) and in exhaled breath
… -phase microextraction fiber inserted into a modified RTube™, a common device also used …

Instrumentation and sensors for human breath analysis

MG Simon, CE Davis – Advances in Biomedical Sensing, Measurements …, 2010 – Springer

… to encourage condensation of water … RTube is a more economical and portable method
for breath sampling, but some volatiles may be lost during breath collection as the condensate …

C16

C Robroeks, J van Berkel… – … and monitoring of …, 2010 – cris.maastrichtuniversity.nl

… Noninvasive techniques include measurement of non-volatile inflammatory markers in exhaled
breath condensate, and measurement of volatile inflammatory markers in exhaled breath…

Lung Cancer Does Not Influence Exhaled Breath Condensate PH In COPD Patients

A Bikov, Z Lázár, N Gyulai, E Őri, D Kovács… – B62. LUNG CANCER …, 2010 – atsjournals.org

… , as shown by a decrease in exhaled breath condensate (EBC) pH in these patients. In …
from subjects wearing a nose clip using Rtube (Respiratory Research, Charlottesville, USA)…

Содержание интерлейкина-8, растворимых молекул адгезии и молекул гистосовместимости I класса у больных хронической обструктивной болезнью легких …

НИ Кубышева, ЛБ Постникова, ВВ Новиков… – Иммунопатология …, 2010 – elibrary.ru

… – 1) and molecules HLA class I in a condensate of exhaled air at COPD patients. Data suggest
… ) осуществляли с помощью специальной системы RTUBE™ (Respiratory Research Inc, …

2009

Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients

R Koczulla, S Dragonieri, R Schot, R Bals, SA Gauw… – Respiratory …, 2009 – Springer

… RTube and ECoScreen in the HC group. To study the reproducibility of EBC pH for ECoScreen
and RTube, … Our results on the performance of the RTube and ECoScreen for pH analysis …

Acute and chronic effects of smoking on inflammation markers in exhaled breath condensate in current smokers

AR Koczulla, S Noeske, C Herr, RA Jörres, H Römmelt… – Respiration, 2009 – karger.com

… Analysis of the exhaled breath condensate (EBC) can provide noninvasive markers that …
EBC was obtained during 10 min tidal breathing with a cooled RTube™. pH was determined …

Exhaled Breath Condensate in Obstructive Lung Diseases: A Methodological study

A Davidsson – 2009 – diva-portal.org

… breath condensate (EBC). EBC may then be analysed for various components of interest. …
EBC using either of the two condensers ECoScreen or RTube and (3) to evaluate the value of …

Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis

CR Esther Jr, G Boysen, BM Olsen… – … of Physiology-Lung …, 2009 – journals.physiology.org

… , we cannot definitively exclude the possibility that salivary contamination influenced our
results, although such contamination has not been previously observed with the RTube under …

Application of novel method to measure endogenous VOCs in exhaled breath condensate before and after exposure to diesel exhaust

HF Hubbard, JR Sobus, JD Pleil, MC Madden… – … of Chromatography B, 2009 – Elsevier

… for assaying PVOC biomarkers in exhaled breath condensate (EBC) samples with application
to a … The collection/analysis method is based on condensation of normal (at rest) exhaled …

Comparative analysis of selected exhaled breath biomarkers obtained with two different temperature-controlled devices

F Hoffmeyer, M Raulf-Heimsoth, V Harth… – BMC pulmonary …, 2009 – Springer

… pH was demonstrated using RTube at a starting temperature … A warm-up during condensation
is observed using RTube or … limitations as exhaled breath condensates on a teflon coated …

An electronic nose distinguishes the exhaled breath condensates of alpha-1-antitrypsin deficiency patients and healthy controls

AR Koczulla, A Hattesohl, S Noeske… – …, 2009 – thieme-connect.com

… analyze and distinguish the VOCs in exhaled breath condensate (EBC) of patients with α 1
-… from ten HCs and ten AATD patients with the RTube by ten minutes of tidal breathing. 250µl …

Endogenous levels of five fatty acid metabolites in exhaled breath condensate to monitor asthma by high-performance liquid chromatography: electrospray tandem …

ML Nording, J Yang, CM Hegedus… – IEEE sensors …, 2009 – ieeexplore.ieee.org

… Our results show that RTube in combination with LC-ESI-MS/MS are sufficient to detect
fatty acid metabolites in EBC, but for these lipophilic compounds plastic or rubber collection …

Distinguishing the exhaled breath condensates of two pa-tient groups with an electronic nose

A Hattesohl, S Noeske, R Bals… – German Conference … – informatik.uni-halle.de

… analyze and distinguish the VOCs in exhaled breath condensate (EBC) of patients with
α1-… The EBC was collected from ten HCs and ten AATD patients with the RTube [Res] by ten …

Assessment of airway inflammation by exhaled breath condensate and impedance due to gastroesophageal reflux disease (GERD)

Y Shimizu, K Dobashi, A Nagoshi… – … & Allergy-Drug …, 2009 – ingentaconnect.com

… Measurement of exhaled breath condensate (EBC) is performed by cooling and collecting
the airway lining fluid contained in exhaled air. A decrease of pH and an increase of the 8- …

A longitudinal study to assess the presence of manganese in blood and exhaled breath condensate following acute inhalation exposure to welding fumes

JD Richman – 2009 – search.proquest.com

… Temperature is not controlled during EBC collection with the Rtube, because it uses an …
are much more expensive than the Rtube making the use of Rtubes more feasible for a small-…

Assessment of exhaled breath condensate ph in asthmatic children

M Shaheen, MM Farid, AH Abdel Karim, NK Hazaa – EJB, 2009 – essb-eg.org

… One study has shown that condensate CO2 partial pressure … condensate pH values to
date.(12) However, another study has shown that EBC pH values in samples obtained by RTube …

Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children

L Liu, R Poon, L Chen, AM Frescura… – Environmental …, 2009 – ehp.niehs.nih.gov

… Measurements of mediators in exhaled breath condensate have been used to better
understand the pathological mechanisms of airway diseases such as asthma, chronic obstructive …

Exhaled breath analysis: novel approach for early detection of lung cancer

HP Chan, C Lewis, PS Thomas – Lung Cancer, 2009 – Elsevier

… In this review, we will briefly describe exhaled breath and exhaled breath condensate, and
discuss their potential as a novel approach for investigating lung cancer and its associated …

Gene promoter methylation assayed in exhaled breath, with differences in smokers and lung cancer patients

W Han, T Wang, AA Reilly, SM Keller, SD Spivack – Respiratory Research, 2009 – Springer

… DNA methylation in exhaled breath condensate, we applied our … , and adapted it to exhaled
breath condensate (EBC) from lung … EBC is collected in a handheld, disposable RTube ® …

Pulmonary and Systemic Increase of alpha 1-Antitrypsin in Acute Exacerbated COPD Patients.

AR Koczulla, S Noeske, C Herr… – A39. COPD …, 2009 – atsjournals.org

… Measurement of exhaled breath condensate (EBC) is a non invasive method to investigate
… Methods: EBC from all individuals was collected with the RTube™ device by gently breathing …

Nitric oxide in airway inflammation

J Liu – 2009 – unsworks.unsw.edu.au

… ® than siliconised glass tubes or RTube® but it gave factitiously … Relationship between
exhaled breath condensate volume … Exhaled breath condensate as a method of sampling airway …

Methodological improvements for detection of volatile and non-volatile breath biomarkers

MG Simon – 2009 – search.proquest.com

… exhaled breath condensate (EBC) … The RTube is a more economical and portable method
for breath sampling, but some volatiles may be lost during breath collection as the condensate …

Breathe in, breathe out: using the airway to combat cancer (Proceedings)

KA Selting – 2009 – dvm360.com

… After 15-20 minutes of normal breathing, condensate was collected from the inner chamber
… The RTube® is a unique tool used for EBC investigation and evaluation that may be able to …

Biomarkers obtained by non-invasive methods in patients with COPD: where do we stand, what do we expect?

G Hillas, S Loukides, K Kostikas… – Current medicinal …, 2009 – ingentaconnect.com

… The commonly used Exhaled Breath Condensate (EBC) methodologies in COPD patients
… portable devices using an aluminum cylinder for cooling (RTube, Respiratory Research Inc., …

Non-invasive measurement of markers of oxidative stress in asbestos-related lung diseases and pulmonary fibrosis

SSM Chow – 2009 – unsworks.unsw.edu.au

… condensate 3-nitrotyrosine in subjects with pulmonary fibrosis compared with normal controls
99 Figure 3.2 Exhaled breath condensate pH … Figure 3.3 Exhaled breath condensate total …

Sampling and mass spectrometry approaches for the detection of drugs and foreign contaminants in breath for homeland security applications

AN Martin – 2009 – search.proquest.com

… One sample was collected 215 minutes after the subject received a manicure with an
RTube modified with PVC tubing which provided inhaled air from a separate room (black trace, …

Przydatność badania kondensatu powietrza wydychanego do oceny wskaźników procesu zapalnego w drogach oddechowych u dzieci chorujących na astmę …

J Jerzyńska, A Brzozowska… – Pediatria Polska, 2009 – Elsevier

… Exhaled breath condensate (EBC) has emerged as a novel noninvasive technique for …
By breathing tidally through a cooling system for 10–15 minutes, adequate condensate can be …

Diseño y evaluación de un equipo para obtener aire espirado condensado

OF Araneda Valenzuela… – Jornal Brasileiro de …, 2009 – SciELO Brasil

… In recent years, the analysis of exhaled breath condensate … for measuring exhaled breath
condensate that is affordable, … destacan por su amplio uso RTube TM (Respiratory Research …

2008

Temperature changes in exhaled breath condensate collection devices affect observed acetone concentrations

BR Loyola, A Bhushan, M Schivo… – Journal of Breath …, 2008 – iopscience.iop.org

… measured during breath condensate collection, using the modified collection tubes containing
thermocouples. Prior to condensate collection trials, we placed the RTube passivecooling …

Matrix effect in exhaled breath condensate interferon-gamma immunoassay

S Hom, B Walsh, J Hunt – Journal of Breath Research, 2008 – iopscience.iop.org

… with investigators and working on the exhaled breath condensate task force, rarely have we
… , Inc., which developed the RTube exhaled breath condensate collectors used in this study. …

Biomarker reproducibility in exhaled breath condensate collected with different condensers

PP Rosias, CM Robroeks, A Kester… – European …, 2008 – Eur Respiratory Soc

… In conclusion, significantly more exhaled breath condensate volume and biomarker …
However, biomarker reproducibility in exhaled breath condensate in healthy adults was not …

Assessment of leukotriene E4 in exhaled breath condensate as a marker of therapeutic effect in moderate persistent asthmatic children

Y Park, J Lee – Journal of Allergy and Clinical Immunology, 2008 – jacionline.org

… Recent studies have shown that the pH of exhaled breath condensate (EBC) could be
predictive of asthma exacerbation and treatment effectiveness. The aim of this study was to …

Morning and Afternoon Repeated Measurements of Offline Exhaled Nitric Oxide and Exhaled Breath Condensate pH

A Divjan, K Ghouri, GL Chew, RL Miller… – Journal of Allergy and …, 2008 – jacionline.org

… RATIONALE: Offline forced exhaled NO (FENO) and exhaled breath condensate (EBC)
pH provide valuable field study tools for assessing airway inflammation; however, better …

Adenosine triphosphate in exhaled breath condensate of healthy subjects and patients with chronic obstructive pulmonary disease

Z Lázár, E Huszar, T Kullmann, I Barta, B Antus… – Inflammation …, 2008 – Springer

… We aimed to measure breath condensate ATP concentration in health and disease. EBC …
In case of the RTube, the chiller tube was held at –70 ºC before condensate collection. EBC …

Proteomic analysis of exhaled breath condensate from single patients with pulmonary emphysema associated to α1-antitrypsin deficiency

M Fumagalli, L Dolcini, A Sala, J Stolk, L Fregonese… – Journal of …, 2008 – Elsevier

… condensate was collected using an RTube kit (… condense along the walls of the tube.
Subjects were asked to breath in this device while wearing a nose clip. The volume of condensate …

Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma

W Jungraithmayr, C Frings, G Zissel, A Prasse… – …, 2008 – Wiley Online Library

… µL of breath condensate was obtained by means of the R-tube (RTube, Respiratory Research
Inc.… Condensation was produced using a cooling sleeve (−10C) made of aluminium, which …

225 Exhaled leukotriene B4 and nitric oxide in cystic fibrosis

K Bloemen, V Nelen, G Schoeters, K Desager – academia.edu

… Exhaled breath condensate (EBC) is used more and more in … during 15 minutes in a RTube
(Respiratory Research). NO … We examined NE in exhaled breath condensate (EBC) in 53 …

Experimental exposure to wood smoke: effects on airway inflammation and oxidative stress

L Barregard, G Sällsten, L Andersson… – Occupational and …, 2008 – oem.bmj.com

… condensate. Results: Exposure to wood smoke increased alveolar nitric oxide 3 hours
post-exposure while malondialdehyde levels in breath condensate … through the RTube until 80 …

Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis

O Roca, S Gómez-Ollés, MJ Cruz, X Muñoz… – Critical Care, 2008 – Springer

… In otherwise healthy patients undergoing lung resection for cancer, the mean EBC pH
obtained using RTubes™ was 7.8 [17]. Another study of patients undergoing cardiothoracic …

Within-and between-person variability of exhaled breath condensate pH and NH4+ in never and current smokers

R Do, KH Bartlett, W Chu, H Dimich-Ward… – Respiratory …, 2008 – Elsevier

Recent studies have suggested that the collection of exhaled breath condensate (EBC) may
be a viable method in occupational field studies to sample secretions of the lower airway …

Collecting exhaled breath condensate (EBC) with two condensers in series: a promising technique for studying the mechanisms of EBC formation, and the volatility of …

M Corradi, M Goldoni, A Caglieri… – Journal of aerosol …, 2008 – liebertpub.com

… volume of EBC2) is in line with that of the RTube™, but less than that of the EcoScreen, …
biomarkers within it because the more efficient condensation of water obtained by using very low …

Efficacy of Two Breath Condensers: An in Vitro Comparative Study

A Davidsson, K Naidu Sjöswärd, B Schmekel – 2008 – diva-portal.org

… recovered by ECoScreen than by RTube during 20-minutes … surface, creating exhaled breath
condensate (EBC). EBC … of the two condensers ECoScreen or RTube and (3) to evaluate …

Mass spectrometric studies of endogenous thiocyanate in exhaled breath condensates and oral rinses

FA Kero – 2008 – search.proquest.com

… condensates soon followed and has been reported at concentration levels on the order of
pg/… obtained by these methods are known as exhaled breath condensates (EBC). A novel LC-…

The effect of ambient air pollution on respiratory health of school children: a panel study

MJ Epton, RD Dawson, WM Brooks, S Kingham… – Environmental …, 2008 – Springer

… effects of ambient particulate air pollution from wood burning on school-age students in
Christchurch, New Zealand, and to explore the utility of urine and exhaled breath condensate …

Airway responsiveness and inflammation in adolescent elite swimmers

L Pedersen, TK Lund, PJ Barnes, SA Kharitonov… – Journal of allergy and …, 2008 – Elsevier

… , 22 and at visit B we collected exhaled breath condensate (EBC) followed by a eucapnic
voluntary … Exhaled breath condensate samples were collected by using RTubes (Respiratory …

Extracellular purines are biomarkers of neutrophilic airway inflammation

CR Esther, NE Alexis, ML Clas… – European …, 2008 – Eur Respiratory Soc

… , ATP levels were measured using luminometry in exhaled breath condensate (EBC) from 14
children with CF … EBC was recovered from the RTube TM and frozen at -80C until analysis. …

Jill M Ferdinands*, Carol A Gotway Crawford2, Roby Greenwald3

D Van Sickle, E Hunter… – Environmental …, 2008 – ehjournal.biomedcentral.com

… ), and collected 5-minute breath condensate samples (Rtube®, Respiratory Research,
Charlottesville, VA) from each participant. Breath condensate sample were collected during tidal …

Pretreatment with albuterol versus montelukast for exercise‐induced bronchospasm in children

HH Raissy, M Harkins, F Kelly… – … : The Journal of Human …, 2008 – Wiley Online Library

… Measurement of exhaled breath condensate was performed at the … condensate were
collected at the beginning of study visits 1 and 2 with use of a disposable collection kit (RTube; …

Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation

K Terada, S Muro, S Sato, T Ohara, A Haruna… – Thorax, 2008 – thorax.bmj.com

… We also investigated the usefulness of exhaled breath condensate (EBC) pH for reflecting
airway inflammation and acid reflux, by analysing the association with GORD symptoms and …

Do newer monitors of exhaled gases, mechanics, and esophageal pressure add value?

RL Owens, WS Stigler, DR Hess – Clinics in chest medicine, 2008 – Elsevier

… Exhaled breath condensate (EBC) offers a noninvasive … The RTube is a disposable collection
system consisting of a … higher when compared with the RTube; however, there was no …

Can we predict development of COPD?

A Davidsson, G Stratelis, F Acevedo, B Schmekel – 2008 – diva-portal.org

… certain biomarkers in exhaled breath condensate (EBC), saliva … surface, creating exhaled
breath condensate (EBC). EBC … either of the two condensers ECoScreen or RTube and (3) to …

Relationship between asthma control and activity limitation: Insights from the REACT study

T Haselkorn, CA Jones, H Chen, M Rhoa… – Journal of Allergy and …, 2008 – jacionline.org

… RATIONALE: Offline forced exhaled NO (FENO) and exhaled breath condensate (EBC)
pH provide valuable field study tools for assessing airway inflammation; however, better …

EXHALED BREATH-GENERATED AEROSOLS OF MYCOBACTERIUM TUBERCULOSIS IN PATIENTS WITH ACTIVE P ULMONARY TUBERCULOSIS DURING …

H Kawada, M Yamazato, Y Shinozawa… – Kekkaku …, 2008 – jstage.jst.go.jp

… RTubeは,一 方向の気流を確保する必要上,回 路内に スリットが… We also prepared an exhaled
breath condensate by cooling … The exhaled breath condensates were also negative in 24 …

Exhaled nitric oxide: a useful biomarker of acute respiratory health effects resulting from exposure to ambient air pollution?: a pilot study in Conyers, Georgia

L Richards – 2008 – mspace.lib.umanitoba.ca

… Health effect measures included lung function, non-invasive biomarkers obtained from
exhaled breath (exhaled nitric oxide and constituents of exhaled breath condensate), and …

小児気管支喘息の気道炎症評価 (呼気凝集液)

勝沼俊雄, 飯倉克人 – 日本小児アレルギー学会誌, 2008 – jstage.jst.go.jp

… Increased interleukin-4 and decreased interferon-γ in exhaled breath condensate of …
Exhaled breath condensate (EBC) is expected as a safe, comparatively handy, non-invasive …

塗抹陽性肺結核における安静呼気エアゾル中の結核菌について

川田博, 山里将也, 篠沢陽子, 鈴木喜久雄, 大谷すみれ… – 結核, 2008 – jlc.jst.go.jp

… RTubeは,一 方向の気流を確保する必要上,回 路内に スリットが… We also prepared an exhaled
breath condensate by cooling … The exhaled breath condensates were also negative in 24 …

Mesure de l’inflammation pulmonaire dans la mucoviscidose

M Fayon, R Chiron, M Abely – Revue des maladies respiratoires, 2008 – Elsevier

… exhaled breath condensate) est obtenu par condensation de … le patient et la chambre de
condensation. Il existe plusieurs … que les tubes en téflon (Rtube) qui sont moins utilisés dans …

2007

Differences in exhaled breath condensate pH measurements between samples obtained with two commercial devices

L Prieto, A Ferrer, J Palop, J Domenech, R Llusar… – Respiratory …, 2007 – Elsevier

… condensate (EBC) collections, using the RTube collection system and the EcoScreen
condenser. EBC pH was measured immediately after collection and after storage at −80 C for 8 …

Collection devices influence the constituents of exhaled breath condensate

J Liu, DH Conrad, S Chow, VH Tran… – European …, 2007 – Eur Respiratory Soc

… The EcoScreen® system had the highest amount of total protein levels in EBC compared
with either the glass tube or the RTube® and it also showed superior inter-day repeatability in …

Exhaled breath condensate: an overview

J Hunt – Immunology and allergy clinics of North America, 2007 – Elsevier

… RTube Respiratory Research, USA More total EBC collections performed using RTube than
… requires optional cooling unit, otherwise condensation temperature is chosen by cooling …

Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis

EH Baker, N Clark, AL Brennan… – Journal of applied …, 2007 – journals.physiology.org

… was collected by exhalation through a one-way valve into a cooled, 22.2-cm-long RTube (…
Retrieved condensate was stored at −20C. Plastics other than RTubes were washed in …

Determinants of variability of protein content, volume and pH of exhaled breath condensate

K Bloemen, G Lissens, K Desager, G Schoeters – Respiratory medicine, 2007 – Elsevier

… Exhaled breath condensate was collected using a RTube (Respiratory Research, Inc). The
… the condensate was measured immediately using a calibrated 1 ml pipette. The condensate …

Exhaled breath condensate mediators in mechanically ventilated brain-injured patients with no acute lung injury are mostly related to markers of systemic …

I Korovesi, E Papadomichelakis, O Livaditi… – Critical Care, 2007 – Springer

Methods Patients were ventilated with 8 ml/kg tidal volume and were put either on PEEP= 0 (ZEEP,
n= 12) or 8 cmH 2 O (PEEP, n= 15). EBC was collected using the RTube device (…

Exhaled breath condensate pH in infants and children with acute and recurrent wheezy bronchitis

C Vogelberg, C Würfel, A Knoetzsch… – Pediatric …, 2007 – Wiley Online Library

… The aim of our study was therefore to evaluate the possibility of sampling breath condensate
with a modified commercially available breath condensate sampler in these young children, …

Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics

S Komakula, S Khatri, J Mermis, S Savill, S Haque… – Respiratory …, 2007 – Springer

… Exhaled breath condensate (EBC) was collected using the Rtube, a non-invasive breath
condensate collection device (Charlottesville, VA). To produce the condensate we used a metal …

A Novel Non-Invasive Method of Detecting Galactomannan in Suspected Pulmonary Aspergillosis.

SR Doffman, LJ Griffiths, C Lim, S Vinnicombe, M Wilks… – Blood, 2007 – Elsevier

… Exhaled breath condensate (EBC) collection provides a non-… cooled insulated metal sleeve
(RTube®, Respiratory Research… Exhaled breath condensate (EBC) collection provides a non-…

Exhaled breath biomarkers in asthmatic children

M Corradi, C Zinelli, C Caffarelli – Inflammation & Allergy-Drug …, 2007 – ingentaconnect.com

… markers in both exhaled breath and condensate have emerged as a possible non invasive
… A comparison between two different devices; RTubes and EcoScreen, for collecting EBC …

Occasional Survey Noninvasive Monitoring of Airway Inflammation in Childhood Asthma

TF Leung, GWK Wong – HK J Paediatr (new series), 2007 – hkjpaed.org

… markers of inflammation in exhaled breath condensate. This paper … Exhaled breath condensate
(EBC) is a rapidly growing field … commercial devices (eg EcoScreen, RTube) or by home-…

2006

Comparison of two methods for exhaled breath condensate collection

OU Soyer, EA Dizdar, O Keskin, C Lilly, O Kalayci – Allergy, 2006 – Wiley Online Library

… within the RTube TM cooling increases to ambient temperatures over the recommended
time course of a condensate collection maneuver. Moreover, condensate collection occurs on a …

Clinical and technical factors affecting pH and other biomarkers in exhaled breath condensate

TF Leung, CY Li, E Yung, EKH Liu… – Pediatric …, 2006 – Wiley Online Library

… However, we found pH values to be significantly different in EBC obtained by RTube and
EcoScreen. There were wide limits of agreement (Fig. 4) and a low correlation between pH …

Identification of acid reflux cough using serial assays of exhaled breath condensate pH

J Hunt, Y Yu, J Burns, B Gaston, L Ngamtrakulpanit… – Cough, 2006 – Springer

… kit consisting of 8 disposable RTube EBC collectors and a … cool temperature for condensation
in the RTube collection system. … time of collection on the RTube label along with checking a …

Exhaled breath condensate pH and childhood asthma: unselected birth cohort study

NC Nicolaou, LA Lowe, CS Murray… – American journal of …, 2006 – atsjournals.org

… Methods: Within the context of a prospective population-based birth cohort, EBC was collected
from 630 children at age 8 yr using the RTube (pH measured after deaeration with argon). …

Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate

PP Rosias, CM Robroeks, HJ Niemarkt… – European …, 2006 – Eur Respiratory Soc

Exhaled breath condensate collection is not yet standardised and biomarker measurements
are often close to lower detection limits. In the current study, it was hypothesised that …

Normative data for pH of exhaled breath condensate

AO Paget-Brown, L Ngamtrakulpanit, A Smith… – Chest, 2006 – Elsevier

… Measurement of pH is one of the simplest and most technically validated biomarkers
studied in exhaled breath condensate (EBC). The pH of EBC has been found to be lower than …

VARIATION IN EXHALED BREATH CONDENSATE PH, VOLUME AND TOTAL PROTEIN CONCENTRATION

K Bloemen, K Desager, G Schoeters – International Journal on …, 2006 – elibrary.ru

… Collection of exhaled breath condensate (EBC) is a non-invasive method to study airway …
during oral tidal breathing for 15 min using a RTube (Respiratory Research, Inc). No food was …

Optimising hydrogen peroxide measurement in exhaled breath condensate

WM Brooks, H Lash, AJ Kettle, MJ Epton – Redox Report, 2006 – Taylor & Francis

… nitric oxide measurement and analysis of exhaled breath condensate (EBC). EBC is the …
using home-made or commercial devices such as ECoScreen™ and RTube™. EBC can be …

Acid-base equilibrium in exhaled breath condensate of grain elevator workers

R Do – 2006 – open.library.ubc.ca

… placed over the Rtube™ to maintain a suitable temperature for the condensation process
to … The Rtube™ is held upright and this results in the condensation chamber to be at a more …

2005

Exhaled breath condensate analysis in patients with COPD

P Montuschi – Clinica Chimica Acta, 2005 – Elsevier

… 2), the condensation chamber is a disposable polypropylene tube which is … RTube is suitable
for collection of EBC samples which can be stored in the freezer at home. Using the RTube, …

Exhaled breath condensate pH assays are not influenced by oral ammonia

K Wells, J Vaughan, TN Pajewski, S Hom… – Thorax, 2005 – thorax.bmj.com

… Exhaled breath condensate was collected during oral tidal breathing using the RTube™ EBC
… For intubated collections the RTube condenser was attached early in the exhalation circuit …

Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic children

T Leung, GWK Wong, FWS Ko, C Li, E Yung… – International archives of …, 2005 – karger.com

… in our recent study in which EBC was collected using RTubes [18, 26]. We believe that our
results … In the present study, disposable RTubes was used to collect EBC as condensed liquid …

Assaying all of the nitrogen oxides in breath modifies the interpretation of exhaled nitric oxide

TA Nguyen, J Woo-Park, M Hess, M Goins… – Vascular …, 2005 – Elsevier

… gases and solutes in exhaled breath condensate therefore are increasingly relied upon to

Lower Limit of Normal Is Better Than 70% or

JE Hansen – Eur Respir J, 2005 – researchgate.net

… The products are RTube and Aeriflux. The company also … Exhaled-breath condensate
pH can be safely and continu… Exhaled breath condensate pH in infants and children with …

Biomarkers for Asthma: Are They Useful Clinical Tools?

TF Leung – Med Bull, 2005 – Citeseer

… commercial devices (eg EcoScreen, RTube) or by home-made … chemokine in exhaled breath
condensate and plasma from … Exhaled breath condensate pH is a robust and reproducible …

2004

Exhaled breath condensate in children: pearls and pitfalls

PPR Rosias, E Dompeling… – Pediatric allergy and …, 2004 – Wiley Online Library

… , or the portable Rtube breath condensate collector which consists of a re-usable and pre-cooled
aluminium sleeve, placed over the outside of a disposable vertical condensation or …

Analysis of Th2-specific chemokines in exhaled breath condensate from asthmatic children

TF Leung, GWK Wong, FWS Ko, CY Li… – Journal of Allergy and …, 2004 – Elsevier

… Exhaled breath condensate was collected by disposable collection kits (RTubes, Respiratory
Research Inc., Charlottesville, VA, USA) whereas fractional exhaled nitric oxide level (…

and pitfalls

RAMG Donckerwolcke – 2004 – researchgate.net

… This is not possible when the condensate is collected in frozen condition, as with the
ECOscreen. The temperature of the cooling sleeve of the Rtube breath condensate collector can be …

The relation between obesity and asthmatic airway inflammation

TF LeungCY Li, CWK Lam, CSS Au… – Pediatric allergy and …, 2004 – Wiley Online Library

… analyzer, whereas LTB 4 concentrations in exhaled breath condensate (EBC) were quantified
using … breath condensate The EBC was collected using a disposable collection kit (RTube; …

A Comparison of Exhaled Breath Nitric Oxide Between Old and Young Individuals

RL Gordon – 2004 – core.ac.uk

… condensate collection and deaeration of the condensate were performed as has been described
in the literature by using the RTube™ … was taken to be the pH of the condensate for that …

Nichtinvasive Verfahren zum Nachweis der Atemwegsentzündung im Vergleich Kosten-Nutzen-Wertigkeit

O Holz, RA Jörres – Pneumologie, 2004 – thieme-connect.com

… The analysis of other compounds of exhaled air, particularly those of exhaled breath condensate
(… 30€ bei der Rtube hoch, aber beispielsweise beim Ecoscreen durch den geringeren …

Gehauchte Diagnosen? Zum Potenzial von Atemkondensatuntersuchungen

C Gessner, S Hammerschmidt, H Kuhn, H Wirtz – Pneumologie, 2004 – thieme-connect.com

… des so genannten Atemkondensates (AK entspricht exhaled breath condensate: EBC) dar.
In der … Das RTube™ hingegen besteht aus einer Plastikröhre, um die ein im Gefrierschrank …

2003

Exhaled breath condensate pH is a robust and reproducible assay of airway acidity

J Vaughan, L Ngamtrakulpanit… – European …, 2003 – Eur Respiratory Soc

… condensate collection was performed using the RTube TM … rapid breathing through the
RTube condenser. ETCO 2 values … min using the standard RTube condensation equipment, with …

2002

Expression and activity of pH-regulatory glutaminase in the human airway epithelium

JF Hunt, E Erwin, L Palmer, J Vaughan… – American journal of …, 2002 – atsjournals.org

… Subjects performed quiet tidal breathing for 5 min, exhaling into a plastic RTube disposable
breath condensation collection device (Respiratory Research, Inc., Charlottesville, VA). …