RTubeVOC

Discover RTubeVOC™ solutions for simultaneous EBC and Volatile Organic Compound (VOC) sampling. Unveil how this dual-purpose system refines breath biomarker studies, capturing both liquid and gaseous signatures for comprehensive respiratory research.

Monitor airway biomarkers from baseline to peak exposure to washout with serial collections of Exhaled Breath Condensate

Did the Drug Fail, or Did the Measurement Fail?

Breath Analysis, RTube

Exhaled breath condensate (EBC) is a non-invasive tool that provides airway-level biological context in early-phase respiratory drug development, helping to distinguish whether ambiguous trial results are due to drug failure or inadequate measurement. EBC is most valuable when the pharmacodynamic question is lung-compartment specific and cannot be answered by blood or FeNO, but its biomarkers are exploratory and require a pre-specified analysis plan for meaningful interpretation. While EBC does not provide validated endpoints, its inclusion can inform critical development decisions by adding mechanistic insight that systemic measures alone cannot offer.

Effectiveness of Exhaled Breath Condensate Collection Using RTube® and Cooling Sleeve Chilled in Household Freezer

Effectiveness of Exhaled Breath Condensate Collection Using RTube® and Cooling Sleeve Chilled in Household Freezer

Publications, Research, RTube

Chilled in a household freezer, the RTube® reliably collects Exhaled Breath Condensate for breath analysis and breath biomarkers. This study shows yields remain near-constant across a wide temperature range, reinforcing RTube’s consistent performance in real-world clinical conditions.

lung cancer detection rtube concept

Journal Article Summary – Measuring RNA in Breath Condensate

Breath Analysis, How To, Publications

The RTube has successfully been used to isolate RNA, microRNA, and DNA from Exhaled Breath Condensate (EBC). While the collection process of EBC is similar for each target, the isolation steps differ. This Journal Article Summary, based on Dr. Guillermo Barreto’s EMBO Medicine study, highlights a non-invasive approach to nucleic acid isolation for early-stage lung cancer detection.

An Evolving Standard for Exhaled Biomarkers in Lung Disease Meets Old-Fashioned Consistency

An Evolving Standard for Exhaled Biomarkers in Lung Disease Meets Old-Fashioned Consistency

Breath Analysis, Research, RTube

Delve into emerging guidelines that standardize exhaled biomarker collection and analysis. Understand how they shape the future of respiratory diagnostics and research.

FDA Commentary on Biomarker Qualification

FDA Commentary on Biomarker Qualification

Breath Analysis, Research

Learn how recent FDA insights shape the qualification process for breath biomarkers. Discover the regulatory considerations that guide research and product approval.

The Drug-Device Breath Test

The Drug-Device Breath Test

Breath Analysis

See how combining pharmaceuticals with breath analysis devices can revolutionize patient monitoring and therapy. Learn about challenges and innovations in this fast-growing field.

Acid Breath Test May Help Identify Reopening of Collapsed Alveoli in ARDS

Acid Breath Test May Help Identify Reopening of Collapsed Alveoli in ARDS

Breath Analysis, Publications, Research

Discover how an acid breath test could reveal critical changes in alveolar function for ARDS patients. Gain insights into potential clinical impact and future applications.

Cytokines

A Simple Method for Comparing Cytokine Levels in Breath

Breath Analysis, How To, Research

Discover a streamlined approach to measure cytokine levels in Exhaled Breath Condensate (EBC), advancing breath biomarker research by simplifying the comparison of inflammatory markers across different breath analyses.

MicroRNA in Exhaled Breath May Help Predict Lung Cancer

MicroRNA in Exhaled Breath May Help Predict Lung Cancer

Breath Analysis, Publications, Research, RTube

Explore how microRNA in Exhaled Breath Condensate (EBC) could provide a non-invasive tool for early lung cancer detection, showcasing breath biomarker breakthroughs that may transform clinical diagnostics.

Selected Exhaled Biomarker Abstracts from ATS 2015

Selected Exhaled Biomarker Abstracts from ATS 2015

Breath Analysis, Publications, Research

Discover selected exhaled biomarker abstracts from ATS 2015, spotlighting new findings to advance respiratory research and clinical practice.

What Makes a Breath Test Clinically Useful?

What Makes a Breath Test Clinically Useful?

Breath Analysis, Research

Uncover factors that elevate a breath test from concept to clinical relevance. Find out what clinicians, researchers, and regulatory bodies value in breath biomarker validation.

The Next Big Breath Test

The Next Big Breath Test

Breath Analysis, Research, RTubeVOC

Explore which cutting-edge breath biomarkers are poised to transform diagnostics. Gain insights into the latest research and potential clinical applications.

Snapshot: Texas’ Impact on Exhaled Biomarker Research

Snapshot: Texas’ Impact on Exhaled Biomarker Research

Discover how Texas-driven research propels breakthroughs in breath biomarkers and breath analysis. This snapshot explores cutting-edge initiatives shaping global EBC innovation.

The Study of Exhaled Breath Condensate pH

The Study of Exhaled Breath Condensate pH

Breath Analysis, How To, Publications, Research

Investigate how pH measurement in Exhaled Breath Condensate (EBC) can gauge respiratory inflammation and disease progression, supporting early diagnosis and tailored treatment.

Cytokines

Cytokines in Exhaled Breath Condensate (EBC) – Part 1

Breath Analysis, Publications, Research, RTube

Uncover how cytokines in EBC reveal critical biomarkers for respiratory inflammation. This first installment shows how breath analysers and EBC collection can shed new light on disease pathways and targeted therapies.

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